Yaounde University Hospital Centre and Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Cameroon, South Africa.
Diabet Med. 2012 Sep;29(9):e334-7. doi: 10.1111/j.1464-5491.2012.03620.x.
To determine the prevalence and effects of sickle cell trait on metabolic control in a Cameroonian diabetic population in a tertiary care setup.
This was a cross-sectional study involving 73 consecutive outpatients with Type 2 diabetes recruited from the Yaounde National Diabetes and Obesity Centre. Sickle cell trait status was based on haemoglobin electrophoresis. Metabolic control was assessed by plasma glucose and HbA(1c), and comparisons made between participants with and without sickle cell trait, with adjustment for confounders through linear regressions models.
The prevalence of sickle cell trait was 19%, without sex difference, and comparable with figures in individuals without diabetes in this setting. Participants with diabetes and sickle cell trait were older than the non-trait participants (66 vs. 58 years, P = 0.02). Otherwise, clinical and biological profile including indicators of metabolic control were similarly distributed between trait and non-trait participants (all P >0.08). After adjustment for confounders, sickle cell trait was unrelated to fasting glucose (β = 0.02; 95% confidence interval -37.68-43.30) and HbA(1c) (β = -0.03, 95% confidence interval -1.18-0.93), and did not affect the relationship between the two markers of diabetes control (β = -0.03, 95% confidence interval -1.18-0.89).
Sickle cell trait was as frequent in this subgroup of patients with Type 2 diabetes as in the general population, suggesting no specific association with diabetes. It does not affect the metabolic control of diabetes. However, how this translates into long-term outcome needs to be fully elucidated in this setting, with an increasing population with both sickle cell trait and diabetes mellitus.
在喀麦隆一家三级保健机构中，确定镰状细胞特征在 2 型糖尿病患者中的流行情况及其对代谢控制的影响。
这是一项横断面研究，共纳入 73 例连续的 2 型糖尿病门诊患者，均来自雅温得国家糖尿病和肥胖中心。镰状细胞特征状态基于血红蛋白电泳确定。通过血浆葡萄糖和 HbA1c 评估代谢控制，并通过线性回归模型调整混杂因素后，比较有和无镰状细胞特征的参与者之间的差异。
镰状细胞特征的患病率为 19%，无性别差异，与该人群中无糖尿病者的患病率相当。患有糖尿病和镰状细胞特征的参与者比无特征的参与者年龄更大（66 岁比 58 岁，P = 0.02）。否则，临床和生物学特征，包括代谢控制指标，在特征和非特征参与者之间分布相似（所有 P >0.08）。在调整混杂因素后，镰状细胞特征与空腹血糖（β = 0.02；95%置信区间 -37.68-43.30）和 HbA1c（β = -0.03，95%置信区间 -1.18-0.93）无关，并且不影响两种糖尿病控制标志物之间的关系（β = -0.03，95%置信区间 -1.18-0.89）。
在该 2 型糖尿病亚组患者中，镰状细胞特征与一般人群一样常见，提示其与糖尿病无特殊关联。它不会影响糖尿病的代谢控制。然而，在这种情况下，它如何转化为长期结果，需要在这个镰状细胞特征和糖尿病患病率均增加的人群中进行充分阐明。
