Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Diabet Med. 2010 Sep;27(9):1012-6. doi: 10.1111/j.1464-5491.2010.03050.x.
To determine the effect of sickle cell trait on measurement of glycated haemoglobin (HbA(1c)) in African American patients with diabetes mellitus.
This is a retrospective study including 885 outpatients who underwent HbA(1c) testing. Medical record review and sickle cell trait determinations based on the HbA(1c) assay were performed in African American participants. The relationship between HbA(1c) and serum glucose measurements was analysed.
Data were obtained from 385 AA (109 with SCT, 22 with haemoglobin C trait and 254 without haemoglobinopathy) and 500 European American patients. In a model created through multivariate repeated-effects regression, the relationship between HbA(1c) and simultaneous serum glucose did not differ between African American subjects with and without the sickle cell trait, but differed between African American subjects without the sickle cell trait and European Americans (P = 0.0002).
Sickle cell trait does not impact the relationship between HbA(1c) and serum glucose concentration. In addition, it does not appear to account for ethnic difference in this relationship between African Americans and whites.
确定镰状细胞特征对糖尿病非裔美国患者糖化血红蛋白（HbA（1c））测量的影响。
这是一项回顾性研究，纳入了 885 名接受 HbA（1c）检测的门诊患者。对非裔美国参与者进行了病历回顾和基于 HbA（1c）检测的镰状细胞特征确定。分析了 HbA（1c）与血清葡萄糖测量之间的关系。
从 385 名非裔美国人（109 名有 SCT，22 名有血红蛋白 C 特征，254 名无血红蛋白病）和 500 名欧洲裔美国人患者中获得了数据。在通过多变量重复效应回归创建的模型中，HbA（1c）与同时的血清葡萄糖之间的关系在有和没有镰状细胞特征的非裔美国人受试者之间没有差异，但在没有镰状细胞特征的非裔美国受试者和欧洲裔美国人之间存在差异（P = 0.0002）。
镰状细胞特征不会影响 HbA（1c）与血清葡萄糖浓度之间的关系。此外，它似乎也不能解释非裔美国人和白人之间这种关系的种族差异。
