Parkinson's Clinic of Eastern Toronto & Movement Disorders Center, Toronto, Ontario, Canada.
Int J Neurosci. 2012 Jul;122(7):363-6. doi: 10.3109/00207454.2012.668727. Epub 2012 Apr 23.
Livedo reticularis (LR) is a "fish-net like" mottling of the skin, and is attributed to a variety of factors. Amantadine, a medication used in Parkinson's disease, has been known to cause LR localized to the lower, and to a rarer extent, the upper extremities. Patient perception of this condition has been severely under-reported and can impact the patient's decision to stop this medication. In this retrospective study, we analyze the perception of five patients presenting with LR and their decision to continue on amantadine. It was seen that patients with the reticularis rash localized in the upper extremities, in addition to the lower extremities, were affected enough to discontinue amantadine despite its useful therapeutic effects. It is imperative that patient perception regarding LR be taken into consideration when initially presented. Furthermore, the decision to change the regiment of amantadine should be individualized according to patient condition and perception of presented rash.
网状青斑（LR）是一种“网状”皮肤斑驳，归因于多种因素。金刚烷胺，一种用于帕金森病的药物，已知会导致 LR 局限于下肢，更罕见的情况下也会累及上肢。患者对这种情况的感知被严重低估，可能会影响他们停止服用这种药物的决定。在这项回顾性研究中，我们分析了五名出现 LR 的患者的感知及其继续服用金刚烷胺的决定。我们发现，网状皮疹不仅局限于下肢，还局限于上肢的患者，即使金刚烷胺有有效的治疗效果，也会因皮疹而停药。当最初出现 LR 时，必须考虑患者的感知。此外，根据患者的病情和对皮疹的感知，应个体化决定是否改变金刚烷胺的治疗方案。
