Mazzocchi G, Malendowicz L K, Nussdorfer G G
Department of Anatomy, University of Padua, Italy.
Peptides. 1990 Jul-Aug;11(4):763-5. doi: 10.1016/0196-9781(90)90192-8.
A bolus IV injection of endothelin-1 (ET-1) (0.5 microgram.kg-1) decreased PRA, without affecting plasma aldosterone (A) concentration. ET-1 exerted a dose-dependent stimulation of basal secretion of A and corticosterone (B) by dispersed zona glomerulosa (ZG) cells, while it did not affect B production by inner adrenocortical cells. ET-1 notably enhanced the secretory response of dispersed ZG cells to a maximal effective concentration of ACTH, but not of either angiotensin II (ANG-II) or potassium. The conclusion is drawn that ET-1 acutely stimulates ZG in rats, by a mechanism probably similar to that underlying the adrenoglomerulotropic actions of ANG-II and potassium.
静脉推注内皮素 -1（ET -1）（0.5微克·千克⁻¹）可降低肾素活性（PRA），而不影响血浆醛固酮（A）浓度。ET -1对分散的球状带（ZG）细胞基础分泌的醛固酮和皮质酮（B）有剂量依赖性刺激作用，而对肾上腺皮质内层细胞的皮质酮生成没有影响。ET -1显著增强了分散的ZG细胞对促肾上腺皮质激素（ACTH）最大有效浓度的分泌反应，但对血管紧张素II（ANG -II）或钾的分泌反应没有影响。得出的结论是，ET -1通过一种可能类似于ANG -II和钾的促肾上腺皮质球状带作用的机制，急性刺激大鼠的ZG。
