Adeyemi E O, Savage A P, Bloom S R, Hodgson H J
Department of Medicine, Royla Postgraduate Medical School, Hammersmith Hospital, London.
Peptides. 1990 Jul-Aug;11(4):869-71. doi: 10.1016/0196-9781(90)90206-k.
The influence of the long-acting somatostatin analogue, SMS 201-995, on FMLP-induced neutrophil elastase release in vitro has been investigated. Doses from 150 ng/ml upwards inhibited elastase release, with 100% inhibition by 2500 ng/ml. Inhibition was demonstrated both by an assay measuring elastase immunometrically and by an assay based on its enzyme activity. The demonstration that SMS 201-995 inhibits protease release from polymorphonuclear leukocytes may have implications for the long-term clinical use of this somatostatin analogue.
长效生长抑素类似物SMS 201-995对体外FMLP诱导的中性粒细胞弹性蛋白酶释放的影响已得到研究。150 ng/ml及以上的剂量可抑制弹性蛋白酶释放，2500 ng/ml时抑制率达100%。通过免疫测定弹性蛋白酶的试验和基于其酶活性的试验均证实了这种抑制作用。SMS 201-995抑制多形核白细胞释放蛋白酶这一发现可能对这种生长抑素类似物的长期临床应用具有重要意义。
