Knapp Charles F, Mathew Rahel, Messina Jane L, Lien Mary H
University of South Florida College of Medicine, Tampa, FL, USA.
Am J Dermatopathol. 2012 May;34(3):e37-9. doi: 10.1097/DAD.0b013e31823e25bb.
Mycosis fungoides (MF) is a primary cutaneous lymphoma characterized by atypical T-lymphocytes that usually presents as patches and plaques on photoprotected areas of the body, such as the groin and buttocks. Classically, the atypical lymphocytes in MF are CD3/CD4 positive with loss of CD7 and less often loss of CD5. In a minority of cases, the atypical infiltrate is CD8 positive. We report a case of biopsy-proven MF in an elderly woman who presented with sclerodermoid lesions on her abdomen and thigh. Immunohistochemical studies revealed coexpression of CD4 and CD8 in a subset of atypical T-lymphocytes, and this was confirmed with flow cytometry. To our knowledge, this is the first report of a CD4/CD8 dual-positive MF.
蕈样肉芽肿（MF）是一种原发性皮肤淋巴瘤，其特征为非典型T淋巴细胞，通常表现为身体光保护部位（如腹股沟和臀部）的斑片和斑块。典型情况下，MF中的非典型淋巴细胞CD3/CD4阳性，CD7缺失，较少见CD5缺失。在少数病例中，非典型浸润为CD8阳性。我们报告一例经活检证实的MF病例，患者为老年女性，腹部和大腿出现硬皮病样病变。免疫组织化学研究显示，一部分非典型T淋巴细胞中CD4和CD8共表达，流式细胞术也证实了这一点。据我们所知，这是CD4/CD8双阳性MF的首例报告。
