[早产儿医院感染性败血症的危险因素及病原菌分布]

[Risk factors and pathogen distribution in premature infants with nosocomial sepsis].

作者信息

Wu Jun, Wu Ben-Qing, Huang Jin-Jie, Luo Liang, Tang Yi

机构信息

Department of Neonatology, Second Clinical Medical College of Jinan University, Shenzhen, Guandong, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2012 Feb;14(2):93-6.

PMID:22357463

Abstract

OBJECTIVE

To investigate the main risk factors and pathogen distribution of nosocomial sepsis among premature infants.

METHODS

The clinical data of 3418 hospitalized premature infants from January 2003 to December 2010 were retrospectively analyzed for the risk factors and pathogen distribution of nosocomial sepsis.

RESULTS

The incidence of neonatal nosocomial sepsis was 3.10% (106/3418), and the median age at diagnosis of neonatal nosocomial sepsis was 19 (4-48) days. The major pathogens of the infections among these premature infants included gram-positive bacteria (45.2%), especially coagulase-negative Staphylococcus (24.3%), and gram-negative bacteria (41.7%), especially Klebsiella pneumoniae (25.2%), as well as fungus (13.0%). Logistic regression analysis showed that the main risk factors included low birth weight, retention of central venous catheters, and long duration of parenteral nutrition (OR: 3.765, 3.051, and 2.998, respectively; P<0.05).

CONCLUSIONS

Low birth weight, retention of central venous catheters, and long duration of parenteral nutrition are the main risk factors for neonatal nosocomial sepsis, whereas the leading pathogen is Klebsiella pneumoniae.

摘要

目的

探讨早产儿医院感染败血症的主要危险因素及病原菌分布情况。

方法

回顾性分析2003年1月至2010年12月期间3418例住院早产儿医院感染败血症的危险因素及病原菌分布情况。

结果

新生儿医院感染败血症的发生率为3.10%（106/3418），确诊新生儿医院感染败血症的中位年龄为19（4 - 48）天。这些早产儿感染的主要病原菌包括革兰氏阳性菌（45.2%），尤其是凝固酶阴性葡萄球菌（24.3%），革兰氏阴性菌（41.7%），尤其是肺炎克雷伯菌（25.2%），以及真菌（13.0%）。Logistic回归分析显示主要危险因素包括低出生体重、中心静脉导管留置和肠外营养持续时间长（比值比分别为3.765、3.051和2.998；P<0.05）。