Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Biol Reprod. 2012 Apr 27;86(4):131. doi: 10.1095/biolreprod.112.098822. Print 2012 Apr.
Ectopic pregnancy (EP) is an enigmatic reproductive disorder. Although tubal EP is difficult to predict, several hypotheses about its etiology have been proposed. In retrospective case-control studies, smoking is associated with an increased rate of EPs in the fallopian tube. Studies of experimental animals in vivo and human fallopian tubal tissues in vitro have suggested mechanisms of fallopian tubal damage and dysfunction induced by nicotine and other smoking-related chemicals that may explain this association. However, the pathogenesis of smoking-induced modulation of implantation leading to tubal EP is largely unknown. Because cigarette/tobacco smoke adversely affects the success of intrauterine implantation, there is a great need to determine how embryo implantation occurs in the fallopian tube in female smokers of reproductive age.
宫外孕（EP）是一种神秘的生殖系统疾病。尽管输卵管妊娠很难预测，但已经提出了几种关于其病因的假说。在回顾性病例对照研究中，吸烟与输卵管妊娠的发生率增加有关。体内实验动物研究和体外人输卵管组织研究表明，尼古丁和其他与吸烟有关的化学物质引起的输卵管损伤和功能障碍的机制可能解释了这种关联。然而，吸烟诱导的着床调节导致输卵管妊娠的发病机制在很大程度上尚不清楚。由于香烟/烟草烟雾会对子宫内着床的成功率产生不利影响，因此非常有必要确定在生殖年龄的吸烟女性中，胚胎是如何在输卵管中着床的。
