Kontomanolis Emmanuel N, Kalagasidou Sofia, Fasoulakis Zacharias
Obstetrics and Gynecology, Democritus University of Thrace, University Hospital of Alexandroupolis.
Department of Obstetrics and Gynecology, Bodosakio General Hospital of Ptolemaida.
Cureus. 2018 Mar 19;10(3):e2344. doi: 10.7759/cureus.2344.
Diagnosis of ectopic pregnancy relies on both ultrasound findings and human chorionic gonadotropin (hCG) measurements but due to the need for serial tests, tubal rupture and death represent major maternal and fetal risks. Early detection of ectopic pregnancy is essential and thus a noninvasive diagnostic tool seems crucial for the prevention of adverse effects since studies suggest there is a specific relationship between ectopic pregnancy and increasing microRNA factors. Human fluids in women with ectopic pregnancy reveal a particular change in comparison to healthy women. In addition to certain placental microRNAs circulating through plasma that present a specific concentration and serum profile, microRNAs seem to be possible biomarkers for the detection of pregnancy complications linked to placental pathologies. The aim of this study is to review current literature considering the expression levels of several circulating microRNAs that have shown to be novel potential biomarkers for the diagnosis of tubal ectopic pregnancy.
异位妊娠的诊断依赖于超声检查结果和人绒毛膜促性腺激素（hCG）测量，但由于需要进行系列检测，输卵管破裂和死亡是主要的母婴风险。早期发现异位妊娠至关重要，因此，一种非侵入性诊断工具对于预防不良反应似乎至关重要，因为研究表明异位妊娠与微小RNA因子增加之间存在特定关系。与健康女性相比，异位妊娠女性的体液呈现出特定变化。除了某些通过血浆循环的胎盘微小RNA具有特定浓度和血清特征外，微小RNA似乎是检测与胎盘病变相关的妊娠并发症的潜在生物标志物。本研究的目的是回顾当前文献，探讨几种循环微小RNA的表达水平，这些微小RNA已被证明是诊断输卵管异位妊娠的新型潜在生物标志物。
