Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland.
Pharmacol Rep. 2011;63(6):1310-5. doi: 10.1016/s1734-1140(11)70695-8.
Psychostimulant (cocaine, amphetamine and its derivatives) addiction is an important health problem with implications in social and economic life. Although mesocorticolimbic dopamine system plays a crucial role in the mechanism responsible for the rewarding effects of these drugs, recent data also show involvement of the brain serotonin (5-HT) system. In the present review we discuss the role of 5-HT(1B) receptors in the psychostimulant addiction on the base of the effects of 5-HT(1B) receptor ligands on the behavioral effects of the psychostimulants in experimental models (sensitization, intracranial self-stimulation, conditioned place preference, self-administration and extinction/reinstatement model) used to assess their addictive properties. Moreover, the effect of long-term treatment with psychostimulants on 5-HT(1B) receptors is also discussed.
兴奋剂（可卡因、苯丙胺及其衍生物）成瘾是一个重要的健康问题，对社会和经济生活都有影响。虽然中脑边缘多巴胺系统在这些药物产生奖励作用的机制中起着至关重要的作用，但最近的数据也表明，脑内 5-羟色胺（5-HT）系统也有参与。在本文综述中，我们根据 5-HT1B 受体配体对实验模型中（敏化、脑内自我刺激、条件性位置偏爱、自我给药和消退/复吸模型）这些药物的行为效应的影响，讨论了 5-HT1B 受体在兴奋剂成瘾中的作用，这些模型被用于评估它们的成瘾特性。此外，我们还讨论了长期使用兴奋剂对 5-HT1B 受体的影响。
