Zandi Soodabeh, Kalia Sunil, Lui Harvey
Psoriasis and Phototherapy Clinic, Vancouver General Hospital, Vancouver, BC, Canada.
Skin Therapy Lett. 2012 Jan;17(1):1-4.
High intensity long-wavelength ultraviolet A (340-400 nm; UVA1) lamps were initially developed as skin research tools; over time they have proven to be useful for treating a number of chronic dermatoses. UVA1 units and dosimetry are strikingly different from conventional UV phototherapy. The therapeutic effect of UVA1 is related to the fact that its long wavelength penetrates the dermis more deeply than UVB. UVA1 radiation induces collagenase (matrix metalloproteinase-1) expression, T-cell apoptosis, and depletes Langerhans and mast cells in the dermis. UVA1 exposure stimulates endothelial cells to undergo neovascularization. Ultraviolet A1 exerts significant therapeutic effects in atopic dermatitis and morphea; there is also evidence for its use in other skin diseases, including cutaneous T-cell lymphoma and mastocytosis.
高强度长波长紫外线A（340 - 400纳米；UVA1）灯最初是作为皮肤研究工具开发的；随着时间的推移，它们已被证明可用于治疗多种慢性皮肤病。UVA1设备和剂量测定与传统紫外线光疗有显著不同。UVA1的治疗效果与以下事实有关：其长波长比UVB更深地穿透真皮。UVA1辐射诱导胶原酶（基质金属蛋白酶 - 1）表达、T细胞凋亡，并使真皮中的朗格汉斯细胞和肥大细胞减少。UVA1照射刺激内皮细胞进行新血管形成。紫外线A1在特应性皮炎和硬斑病中发挥显著治疗作用；也有证据表明其可用于其他皮肤病，包括皮肤T细胞淋巴瘤和肥大细胞增多症。
