Rombold S, Lobisch K, Katzer K, Grazziotin T C, Ring J, Eberlein B
Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.
Photodermatol Photoimmunol Photomed. 2008 Feb;24(1):19-23. doi: 10.1111/j.1600-0781.2008.00328.x.
Investigation of the efficacy of ultraviolet (UV) A1 phototherapy on atopic eczema, scleroderma, granuloma annulare, urticaria pigmentosa, prurigo nodularis, lichen sclerosus et atrophicus, T-cell lymphoma, keratosis lichenoides chronica, chronic urticaria and some rare, sclerosing skin diseases.
The data of 230 patients treated with low-dose, medium-dose and high-dose UVA1 therapy during 6 years were retrospectively analysed. The mean single dose (J/cm(2)), the mean number of irradiations and the mean total dose (J/cm(2)) were evaluated. The efficacy of phototherapy was assessed by a grading scale and the number of patients was given in percentage for each group.
Good therapeutic effects of UVA1 therapy were shown in patients with atopic eczema, scleroderma, lichen sclerosus et atrophicus, keratosis lichenoides chronica, prurigo nodularis and with cutaneous T-cell lymphoma. Positive effects in some patients were seen in the urticaria pigmentosa and granuloma annulare group, no change to slight improvement was seen in most of the patients with rare, sclerosing skin diseases and no effect was seen in the chronic urticaria group.
Besides topical and systemic therapy, UVA1 radiation is a good option of treatment in various skin diseases. It is one of the first-line treatments for several sclerotic diseases and it often improves pruritus considerably.
研究长波紫外线（UVA1）光疗对特应性皮炎、硬皮病、环状肉芽肿、色素性荨麻疹、结节性痒疹、硬化萎缩性苔藓、T细胞淋巴瘤、慢性苔藓样角化病、慢性荨麻疹以及一些罕见的硬化性皮肤病的疗效。
回顾性分析6年间接受低剂量、中剂量和高剂量UVA1治疗的230例患者的数据。评估平均单次剂量（J/cm²）、平均照射次数和平均总剂量（J/cm²）。通过分级量表评估光疗疗效，并给出每组患者的百分比。
UVA1疗法对特应性皮炎、硬皮病、硬化萎缩性苔藓、慢性苔藓样角化病、结节性痒疹和皮肤T细胞淋巴瘤患者显示出良好的治疗效果。色素性荨麻疹和环状肉芽肿组部分患者有积极效果，大多数罕见的硬化性皮肤病患者无变化至略有改善，慢性荨麻疹组无效果。
除局部和全身治疗外，UVA1照射是治疗多种皮肤病的良好选择。它是几种硬化性疾病的一线治疗方法之一，且常能显著改善瘙痒。
