Istituti di: Clinica Medica e Gastroenterologia, Università di Bologna, Bologna, Italy.
Cytotechnology. 1987 Oct;1(1):103-5. doi: 10.1007/BF00351134.
Old subjects exhibit a decline in circulating T cells and an impaired proliferative response to mitogens, plus a relative increase in cells with NK phenotype not associated with a concomitant increase in their cytolitic activity.In the present study a limiting dilution assay was used to evaluate the phenotype, the functional activity and the proliferative capacity of clones obtained from peripheral blood lymphocytes of old and young subjects. CD5+ CD8+ clones from old people showed a significant impairment in their proliferative capacity and a decreased lytic activity against K562 and P815-IgG cell lines.
老年受试者表现为循环 T 细胞减少和对有丝分裂原的增殖反应受损，以及 NK 表型细胞的相对增加，而其细胞溶解活性没有相应增加。在本研究中，使用有限稀释分析来评估从老年和年轻受试者外周血淋巴细胞中获得的克隆的表型、功能活性和增殖能力。老年人群的 CD5+CD8+克隆表现出增殖能力显著受损，对 K562 和 P815-IgG 细胞系的细胞溶解活性降低。
