Laboratoire d'Hématologie, 4 avenue de l'Observatoire, 75006, Paris, France.
Cytotechnology. 1989 May;2(2):111-8. doi: 10.1007/BF00386143.
Retinoic acid (RA) inhibited the in vitro growth of the mouse mast cell tumor line P(815) in a dose- and time-dependent manner. The inhibition was accompanied by an increase in the amount of neutral intracellular mucopolysaccharides. Study of cell cycle kinetics showed that exposure to retinoic acid led to a slowing-down of the cell-cycle progression possibly related to a more differentiated cell population disclosed by microscopy with a lower proliferative capacity. In vivo, delays in both tumor appearance and mouse mortality were observed after injecting RA into mice bearing mastocytomas. These results suggest that RA could be of interest in the treatment of human malignant systemic mastocytosis with proliferation of immature mast cells.
视黄酸（RA）以剂量和时间依赖的方式抑制小鼠肥大细胞瘤系 P（815）的体外生长。抑制伴随着中性细胞内粘多糖含量的增加。细胞周期动力学研究表明，视黄酸的暴露导致细胞周期进展减慢，可能与显微镜下显示的增殖能力较低的更分化的细胞群体有关。在体内，向患有肥大细胞瘤的小鼠注射 RA 后，观察到肿瘤出现和小鼠死亡的时间均延迟。这些结果表明，RA 可能对治疗人类恶性全身性肥大细胞增多症中不成熟肥大细胞的增殖具有重要意义。
