Department of Biochemistry, University of Wisconsin-Madison, 53706, Madison, WI, USA.
Cytotechnology. 1989 Dec;2(4):351-65. doi: 10.1007/BF00364998.
Heparin-binding growth factors modulate diverse biological activities including cellular proliferation, cellular differentiation, morphogenesis, and angiogenesis. Biochemical characterization for two members of the heparin-binding growth factor family, acidic and basic fibroblast growth factors, is extensive, while characterization of the remaining five members is forthcoming. Cell surface receptors have been identified for acidic and basic fibroblast growth factors, but little is known concerning their sites of action in vivo or the mechanisms involved in transducing the energy of growth factor binding to a biological response. An understanding of the biological basis for the diversity of the heparin binding growth factor family and the in vivo actions of these factors will prove a major challenge to future research efforts.
肝素结合生长因子调节多种生物学活性，包括细胞增殖、细胞分化、形态发生和血管生成。肝素结合生长因子家族的两个成员，酸性和成纤维细胞生长因子，的生化特性已得到广泛研究，而其余五个成员的特性正在研究中。已经鉴定出酸性和成纤维细胞生长因子的细胞表面受体，但对于它们在体内的作用部位或将生长因子结合的能量转导为生物学反应的机制知之甚少。对于肝素结合生长因子家族的多样性及其在体内的作用的生物学基础的理解，将是未来研究工作的主要挑战。
