Department of Medicine, VA Sacramento Medical Centre, 10535 Hospital Way, Mather, CA 95655, USA.
Clin Rev Allergy Immunol. 2013 Apr;44(2):109-13. doi: 10.1007/s12016-012-8309-z.
Psoriasis is a lifelong skin disease, affecting about 2% of the global population. Generalized involvement of the body (erythroderma), extensive pustular lesions, and an associated arthritis known as psoriatic arthritis (PsA) are severe complications of psoriasis. Genetic, immunologic, and environmental factors contribute to its pathogenesis. A complete understanding of the pathogenesis of psoriasis and psoriatic arthritis is lacking. Cytokines, chemokines, adhesion molecules, growth factors like NGF, neuropeptides, and T cell receptors all act in an integrated way to evolve into unique inflammatory and proliferative processes typical of psoriasis and PsA. Management of psoriasis requires exemplary skin care along with careful monitoring of arrays of comorbidities which includes arthritis and coronary artery disease. In many ways, psoriasis can be considered a model autoimmune disease. This statement itself is ironic considering that it was not recognized as immune mediated until relatively recently. Fortunately, the immunobiology has made enormous strides and there are now excellent therapeutic options for patients. In this thematic review, we have attempted to provide summaries of not only basic science and clinical research, but also an overview of future research directions.
银屑病是一种终身性皮肤病，影响全球约 2%的人口。全身性受累（红皮病）、广泛脓疱性病变和与之相关的关节炎，即银屑病关节炎（PsA），是银屑病的严重并发症。遗传、免疫和环境因素促成了其发病机制。目前对银屑病和银屑病关节炎的发病机制还不完全了解。细胞因子、趋化因子、黏附分子、神经营养因子（NGF）、神经肽和 T 细胞受体等均以整合的方式发挥作用，从而导致独特的炎症和增殖过程，这是银屑病和 PsA 的典型特征。银屑病的治疗需要进行卓越的皮肤护理，同时还需要仔细监测包括关节炎和冠状动脉疾病在内的多种并发症。在很多方面，银屑病可以被视为一种模型自身免疫性疾病。这一说法本身就具有讽刺意味，因为直到最近才认识到它是由免疫介导的。幸运的是，免疫生物学已经取得了巨大的进展，现在为患者提供了极好的治疗选择。在本次专题综述中，我们不仅尝试总结基础科学和临床研究，还概述了未来的研究方向。
