皮肤免疫及其在银屑病中的失调。
Skin immunity and its dysregulation in psoriasis.
机构信息
Unit of Dermatology, Department of Systems Medicine, University of Rome 'Tor Vergata' , Rome , Italy.
Biochemistry Laboratory, Istituto Dermopatico Immacolata (IDI-IRCCS) , Rome , Italy.
出版信息
Cell Cycle. 2019 Oct;18(20):2581-2589. doi: 10.1080/15384101.2019.1653099. Epub 2019 Aug 15.
Abstract
The skin is a peripheral lymphoid organ, being the first immunological defense against infections as the initial interface between the organism and the external background. The maintenance of the skin immune homeostasis depends on a finely equilibrium of well-regulated relations between different cells and exogenous pathogens. Inflammatory skin diseases are directly linked to the dysregulation of this equilibrium. The present review discusses the role of the immune system, of T cells, in the etiopathogenesis of psoriasis, illustrating a potential rationale for innovative therapeutic intervention.
摘要
皮肤是外周淋巴器官，是机体抵御感染的第一道免疫防线，也是机体与外界环境的初始接触界面。皮肤免疫稳态的维持依赖于不同细胞和外源性病原体之间的精细平衡关系。炎症性皮肤病与这种平衡失调直接相关。本文讨论了免疫系统、T 细胞在银屑病发病机制中的作用，为创新性治疗干预提供了潜在的理论依据。
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