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本文引用的文献

1
Sustained protein synthesis and reduced eEF2K levels in TAp73 mice brain: a possible compensatory mechanism.TAp73 小鼠大脑中持续的蛋白质合成和 eEF2K 水平降低：一种可能的代偿机制。
Cell Cycle. 2018;17(23):2637-2643. doi: 10.1080/15384101.2018.1553341. Epub 2018 Dec 4.
2
Mathematical model identifies effective P53 accumulation with target gene binding affinity in DNA damage response for cell fate decision.数学模型确定了 DNA 损伤反应中 P53 积累与靶基因结合亲和力的有效性，以决定细胞命运。
Cell Cycle. 2018;17(24):2716-2730. doi: 10.1080/15384101.2018.1553342. Epub 2018 Dec 10.
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P53 enhances apoptosis induced by doxorubicin only under conditions of severe DNA damage.P53 仅在严重的 DNA 损伤条件下增强阿霉素诱导的细胞凋亡。
Cell Cycle. 2018;17(17):2175-2186. doi: 10.1080/15384101.2018.1520565. Epub 2018 Sep 22.
4
Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis.新型色氨酸衍生分子通过干扰 Mdm2 激活 p53 促进细胞凋亡。
Cell Cycle. 2018;17(15):1917-1930. doi: 10.1080/15384101.2018.1506664. Epub 2018 Sep 5.
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TNF-α induces autophagy through ERK1/2 pathway to regulate apoptosis in neonatal necrotizing enterocolitis model cells IEC-6.TNF-α 通过 ERK1/2 通路诱导自噬来调节新生儿坏死性小肠结肠炎模型细胞 IEC-6 的凋亡。
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The interplay between mutant p53 and the mevalonate pathway.突变型 p53 与甲羟戊酸途径的相互作用。
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皮肤免疫及其在银屑病中的失调。

Skin immunity and its dysregulation in psoriasis.

机构信息

Unit of Dermatology, Department of Systems Medicine, University of Rome 'Tor Vergata' , Rome , Italy.

Biochemistry Laboratory, Istituto Dermopatico Immacolata (IDI-IRCCS) , Rome , Italy.

出版信息

Cell Cycle. 2019 Oct;18(20):2581-2589. doi: 10.1080/15384101.2019.1653099. Epub 2019 Aug 15.

DOI:10.1080/15384101.2019.1653099
PMID:31416396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6773242/
Abstract

The skin is a peripheral lymphoid organ, being the first immunological defense against infections as the initial interface between the organism and the external background. The maintenance of the skin immune homeostasis depends on a finely equilibrium of well-regulated relations between different cells and exogenous pathogens. Inflammatory skin diseases are directly linked to the dysregulation of this equilibrium. The present review discusses the role of the immune system, of T cells, in the etiopathogenesis of psoriasis, illustrating a potential rationale for innovative therapeutic intervention.

摘要

皮肤是外周淋巴器官，是机体抵御感染的第一道免疫防线，也是机体与外界环境的初始接触界面。皮肤免疫稳态的维持依赖于不同细胞和外源性病原体之间的精细平衡关系。炎症性皮肤病与这种平衡失调直接相关。本文讨论了免疫系统、T 细胞在银屑病发病机制中的作用，为创新性治疗干预提供了潜在的理论依据。