Department of Pediatrics, University of Kırıkkale, Faculty of Medicine, Kırıkkale, Turkey.
Indian J Pediatr. 2012 Nov;79(11):1468-72. doi: 10.1007/s12098-012-0703-2. Epub 2012 Feb 23.
To evaluate the changes in heart rate variability (HRV) in newborns with hypoxic-ischemic encephalopathy (HIE).
Twenty-two newborns (14 boys, 8 girls) with moderate or severe HIE and 24 term neonates with similar gestational and postnatal age for control were included in this study. Normalized low and high frequency components of HRV and their ratio were evaluated for 24-h in newborns with HIE and control subjects.
The newborns with hypoxic-ischemic encephalopathy had significantly lower normalized low frequency (LFn) and low frequency (LF) / high frequency (HF) values and higher normalized high frequency (HFn) values when compared with the control babies. In addition, when the cases with severe HIE are compared with those of moderate HIE, decreased LFn, LF/HF values and also increased HFn values were present in the severe cases.
HIE is associated with reduced sympathetic nervous system activity, and increased parasympathetic nervous system activity and these activities also correlate with the severity of the disease.
评估患有缺氧缺血性脑病（HIE）的新生儿心率变异性（HRV）的变化。
本研究纳入了 22 例中重度 HIE 新生儿（男 14 例，女 8 例）和 24 例胎龄和出生后日龄相似的足月新生儿作为对照。评估 HIE 新生儿和对照组新生儿 24 小时的 HRV 正常低频和高频成分及其比值。
与对照组相比，患有缺氧缺血性脑病的新生儿的正常低频（LFn）和低频（LF）/高频（HF）值明显降低，正常高频（HFn）值明显升高。此外，与中重度 HIE 相比，重度 HIE 患者的 LFn、LF/HF 值降低，HFn 值升高。
HIE 与交感神经系统活动减少、副交感神经系统活动增加有关，这些活动与疾病的严重程度也相关。
