[Correction of protease-protease inhibitor imbalance by intrapulmonary administration of contrical in the treatment of patients with chronic nonspecific lung diseases].

The ratio of proteinases and their inhibitors in bronchoalveolar washings was studied in 38 patients with chronic nonspecific diseases of the lungs. A decrease in the inhibitor potential was detected. Contrical, an inhibitor of proteolytic enzymes, was used in the treatment of the patients. A new procedure for trans-thoracic++ intrapulmonary administration of contrical with an ISI-1 needle jet injector was shown to be efficient. It provided delivery of the drug in optimal daily doses immediately into the inflammation focus.