Vakhidova G A, Kul'berg A Ia
Probl Tuberk. 1990(7):55-7.
The cellular receptor decay products R proteins and resultant product-immunoglobulin complexes, homoreactants showing the properties of natural antibodies and natural anti-sheep erythrocyte antibodies were analysed in their dynamics in 116 patients with infiltrative pulmonary tuberculosis. It was found that small homoreactant levels and relatively low titers of R proteins and natural sheep anti-erythrocyte antibodies were typical of patients with a limited process and favorable course due to effective treatment, the parameters being gradually normalized in their dynamics. In patients with a disseminated destructive process running an unfavorable course, all the values were much higher before the treatment and slightly changed during an ineffective therapy. It is suggested that the findings may be useful in the clinical management of pulmonary tuberculosis to predict its course and outcomes and to evaluate the efficacy of chemotherapy.
对116例浸润性肺结核患者的细胞受体衰变产物R蛋白以及由此产生的产物-免疫球蛋白复合物、具有天然抗体和天然抗绵羊红细胞抗体特性的同源反应物的动态变化进行了分析。结果发现，由于有效治疗，病程有限且预后良好的患者，其同源反应物水平较低，R蛋白和天然抗绵羊红细胞抗体滴度相对较低，这些参数在动态变化过程中逐渐恢复正常。在播散性破坏性病程且预后不良的患者中，所有数值在治疗前都高得多，且在无效治疗期间变化不大。提示这些发现可能有助于肺结核的临床管理，以预测其病程和转归，并评估化疗疗效。
