Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.
Mov Disord. 2012 Jan;27(1):151-5. doi: 10.1002/mds.23975.
We hypothesized that postural instability and cognitive decline in patients with Richardson’s syndrome could be a consequence of reduced thalamic and frontal metabolism. Severe Parkinsonian signs in patients with progressive supranuclear palsy-parkinsonism may be reflected by alterations in putaminal metabolism.
Eleven patients with Richardson’s syndrome, 8 patients with progressive supranuclear palsy-parkinsonism, 12 with Parkinson’s disease, and 10 controls underwent clinical assessment and fluorodeoxyglucose positron emission tomography (PET).
Richardson’s syndrome patients showed pronounced thalamic hypometabolism, and patients with progressive supranuclear palsy-parkinsonism pronounced putaminal hypometabolism, compared to all other investigated groups. The putamen/thalamus uptake ratio differentiated progressive supranuclear palsy-parkinsonism from Richardson’s syndrome (area under the curve 5 0.86) and from Parkinson’s disease (area under the curve 5 0.80) with acceptable accuracy. Frontal hypometabolism was predominantly found in Richardson’s syndrome patients.
Richardson’s syndrome, progressive supranuclear palsy-parkinsonism and Parkinson’s disease showed different metabolic patterns in fluorodeoxyglucose PET.
我们假设，Richardson 综合征患者的姿势不稳和认知能力下降可能是由于丘脑和额叶代谢减少所致。进行性核上性麻痹-帕金森病患者的严重帕金森氏病体征可能反映在壳核代谢的改变上。
11 例 Richardson 综合征患者、8 例进行性核上性麻痹-帕金森病患者、12 例帕金森病患者和 10 例对照组接受了临床评估和氟脱氧葡萄糖正电子发射断层扫描（PET）。
Richardson 综合征患者的丘脑代谢明显降低，进行性核上性麻痹-帕金森病患者的壳核代谢明显降低，与其他所有研究组相比。壳核/丘脑摄取比值可区分进行性核上性麻痹-帕金森病和 Richardson 综合征（曲线下面积 50.86）以及帕金森病（曲线下面积 50.80），具有可接受的准确性。额叶代谢低下主要见于 Richardson 综合征患者。
Richardson 综合征、进行性核上性麻痹-帕金森病和帕金森病在氟脱氧葡萄糖 PET 中表现出不同的代谢模式。
