Pillai Kanchana Soman, Rajeswari Parvathy, Kamble Ravindra B, Gopalan Nair Santhamma Shagos, Chacko Manas, Jayakrishnan Vijay, Ramachandran Ranjini, Avarachan Ayana, Kishore Asha
Parkinson and Movement Disorders Centre, Department of Neurology, Aster Medcity, Kochi, Kerala, India.
Department of Radiology, Aster CMI Hospital, Bengaluru, Karnataka, India.
Mov Disord Clin Pract. 2025 May;12(5):664-669. doi: 10.1002/mdc3.14346. Epub 2025 Feb 4.
The new classification of progressive supranuclear palsy (PSP) subtypes necessitates identifying radiological biomarkers to support the clinical diagnosis.
The goal was to test if magnetic resonance imaging (MRI) morphometry, diffusion tensor imaging (DTI), susceptibility-weighted imaging (SWI), or [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) differentiates PSP subtypes from each other or Parkinson's disease (PD).
Midbrain/pons (M/P) area ratio, middle/superior cerebellar peduncle (MCP/SCP) width ratio, magnetic resonance parkinsonism indices (MRPI and MRPI2) and midbrain antero-posterior (AP) diameter were measured. Region of interest-based DTI, SWI, and FDG-PET analyses were performed.
Four PSP subtypes (n = 85) and 24 PD were studied. MRI morphometry and DTI could differentiate PSP-Richardson syndrome (PSP-RS) from PSP-parkinsonism, PSP-postural instability, and PD (area under curve >0.7). SWI did not differentiate among PSP subtypes or PD. FDG-PET distinguished PSP from PD.
MRI morphometry and DTI differentiated PSP-RS from the other common PSP subtypes and PD and may be tested as a radiological marker of PSP-RS in larger studies.
进行性核上性麻痹（PSP）亚型的新分类需要识别影像学生物标志物以支持临床诊断。
目的是测试磁共振成像（MRI）形态学、扩散张量成像（DTI）、磁敏感加权成像（SWI）或[18F]氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）是否能区分PSP亚型彼此之间以及与帕金森病（PD）。
测量中脑/脑桥（M/P）面积比、中/上小脑脚（MCP/SCP）宽度比、磁共振帕金森指数（MRPI和MRPI2）以及中脑前后径（AP）。进行基于感兴趣区域的DTI、SWI和FDG-PET分析。
研究了4种PSP亚型（n = 85）和24例PD患者。MRI形态学和DTI能够区分PSP-理查森综合征（PSP-RS）与PSP-帕金森综合征、PSP-姿势不稳以及PD（曲线下面积>0.7）。SWI无法区分PSP亚型或PD。FDG-PET能够区分PSP与PD。
MRI形态学和DTI能够区分PSP-RS与其他常见的PSP亚型以及PD，在更大规模研究中可作为PSP-RS的影像学标志物进行测试。
