Lipozencić Jasna, Ljubojević Suzana, Gregurić Sanja
Department of Dermatology and Venereology, Zagreb University Hospital Center, Zagreb, Croatia.
Acta Med Croatica. 2011;65(2):87-96.
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease characterized by itching and typical clinical features, depending on patient age. It is often associated with other atopic diseases such as asthma or allergic rhinitis, resulting from the complex etiology and pathogenesis. It occurs more frequently in people with genetic predisposition for atopic diseases. The intensity and extent of skin lesions (Scoring of Atopic Dermatitis, SCORAD Index) vary significantly among AD patients, depending on whether it is acute or chronic, and there are variations in laboratory parameters, especially immune. In the future, it will be necessary to reach consensus on the new criteria for defining AD instead of the old ones (brought by Hanifin and Rajka 31 years ago). What is needed is effective and safe treatment, and control of the early stages of AD as well as maintaining AD remission. The new therapeutic approach in AD has greatly improved the quality of life of AD patients. As the prevalence of the disease continues to increase, we emphasize the importance of prevention, prompt recognition and optimal treatment of the many patients with AD.
特应性皮炎(AD)是一种慢性复发性炎症性皮肤病,其特征为瘙痒及取决于患者年龄的典型临床特征。由于病因和发病机制复杂,它常与其他特应性疾病如哮喘或过敏性鼻炎相关联。它在有特应性疾病遗传易感性的人群中更常见。根据是急性还是慢性,AD患者的皮肤病变强度和范围(特应性皮炎评分,SCORAD指数)差异显著,并且实验室参数存在差异,尤其是免疫方面。未来,有必要就定义AD的新标准而非旧标准(31年前由哈尼芬和拉伊卡提出)达成共识。需要的是有效且安全的治疗,以及控制AD的早期阶段并维持AD缓解。AD的新治疗方法极大地改善了AD患者的生活质量。随着该疾病患病率持续上升,我们强调对众多AD患者进行预防、及时识别和优化治疗的重要性。