Department of Stomatology, Faculdade de Odontologia da Universidade de São Paulo, USP, São Paulo, SP, Brazil.
Oral Dis. 2012 Sep;18(6):548-57. doi: 10.1111/j.1601-0825.2012.01907.x. Epub 2012 Feb 24.
Keratocystic odontogenic tumors (KOTs) can be treated with Carnoy's solution, although this treatment modality is not free from complications. It is important to verify the incidence of complications after the use of Carnoy's solution and compare these with the literature.
This study verified the effects of a complementary treatment for KOTs and assessed the incidence of such complications as recurrence, infection, sequestrum formation, mandibular fracture, dehiscence, and neuropathy.
Twenty-two KOTs treated with Carnoy's solution combined with peripheral ostectomy were included, and the follow-up period varied from 12 to 78months with a mean of 42.9months. Complications included recurrence (4.5%), dehiscence (22.7%), infection (4.5%), and paresthesia (18.2%). No difference was found among lesions associated (9.1%) or not (0%) with nevoid basal cell carcinoma syndrome (P>0.05). Dehiscence was influenced by marsupialization (P<0.05), and paresthesia was observed exclusively in cases of mandibular canal fenestration (P<0.01).
Complementary treatment with Carnoy's solution and peripheral ostectomy appear to provide efficient treatment for KOTs. Complications originating from the use of the solution are less frequent and less serious than complications associated with cryotherapy. Neuropathy seems to be related to direct contact between the solution and the epineurium.
牙源性角化囊性瘤（KOTs）可以用 Carnoy 溶液治疗，但这种治疗方式并非没有并发症。验证 Carnoy 溶液使用后并发症的发生率并与文献进行比较很重要。
本研究验证了 Carnoy 溶液联合边缘切除术治疗 KOT 的效果，并评估了复发、感染、死骨形成、下颌骨骨折、裂开和神经病变等并发症的发生率。
共纳入 22 例接受 Carnoy 溶液联合边缘切除术治疗的 KOT 患者，随访时间为 12 至 78 个月，平均 42.9 个月。并发症包括复发（4.5%）、裂开（22.7%）、感染（4.5%）和感觉异常（18.2%）。无神经嵴细胞痣综合征相关病变（9.1%）和无神经嵴细胞痣综合征病变（0%）之间的差异无统计学意义（P>0.05）。裂开与袋形术有关（P<0.05），而感觉异常仅发生于下颌骨管开窗病例（P<0.01）。
Carnoy 溶液联合边缘切除术的辅助治疗似乎为 KOT 提供了有效的治疗方法。溶液引起的并发症比冷冻治疗相关的并发症更少见且更轻微。神经病变似乎与溶液与神经外膜的直接接触有关。
