Slusarenko da Silva Yuri, Stoelinga Paul J W, Naclério-Homem Maria da Graça
Department of Oral & Maxillofacial Surgery, Traumatology and Prosthesis, Faculty of Dentistry of the University of São Paulo, Av Prof. Lineu Prestes 2227, Butantã, São Paulo, 05508-000, Brazil.
Department of Oral and Maxillofacial Surgery, Radboud University, Nijmegen, The Netherlands.
Oral Maxillofac Surg. 2019 Jun;23(2):133-147. doi: 10.1007/s10006-019-00754-5. Epub 2019 Mar 2.
This study was conducted in order to gain insight in the actual ratio of odontogenic keratocysts occurring in the tooth-bearing area as compared to the posterior region of the jaws in order to come up with reliable data to base upon a rational treatment policy.
We searched MEDLINE, Web of Science, Scopus, and Cochrane databases for studies reporting on the location of mandibular and maxillary odontogenic keratocysts. All records were independently assessed and a meta-analysis was performed. Risk difference with a confidence interval of 95% of having the lesion in the posterior region versus the tooth-bearing area was the effect measure. P value for the summary effect of < 0.05 was considered statistically significant.
The 2615 records retrieved were reduced to 34 studies to be qualitatively/quantitatively assessed. The pooled values showed that the difference in the clinical risk of having keratocysts in the posterior region of the mandible and in the tooth-bearing area of the maxilla is 21 and 43%, respectively (P < 0.02 and P < 0.00001).
A substantial amount of keratocysts occur in the tooth-bearing area of the jaws, requiring attention.
开展本研究是为了深入了解牙源性角化囊肿在颌骨牙列区与颌骨后部区域出现的实际比例，以便得出可靠数据，为合理的治疗策略提供依据。
我们在MEDLINE、科学网、Scopus和Cochrane数据库中检索了报告下颌骨和上颌骨牙源性角化囊肿位置的研究。对所有记录进行独立评估并进行荟萃分析。以95%置信区间的风险差异作为效应量，比较病变出现在后部区域与牙列区的情况。汇总效应的P值<0.05被认为具有统计学意义。
检索到的2615条记录筛选后得到34项研究进行定性/定量评估。汇总值显示，下颌骨后部区域和上颌骨牙列区发生角化囊肿的临床风险差异分别为21%和43%（P<0.02和P<0.00001）。
大量角化囊肿发生在颌骨牙列区，需要引起关注。
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