University of Navarra, Department of Nutrition, Food Science, Physiology and Toxicology, C/Irunlarrea, 1 31008, Pamplona, Spain.
Expert Opin Ther Targets. 2012 Mar;16(3):269-97. doi: 10.1517/14728222.2012.664134. Epub 2012 Feb 24.
The increasing prevalence of type 2 diabetes mellitus and the negative clinical outcomes observed with the commercially available anti-diabetic drugs have led to the investigation of new therapeutic approaches focused on controlling postprandrial glucose levels. The use of carbohydrate digestive enzyme inhibitors from natural resources could be a possible strategy to block dietary carbohydrate absorption with less adverse effects than synthetic drugs.
This review covers the latest evidence regarding in vitro and in vivo studies in relation to pancreatic alpha-amylase inhibitors of plant origin, and presents bioactive compounds of phenolic nature that exhibit anti-amylase activity.
Pancreatic alpha-amylase inhibitors from traditional plant extracts are a promising tool for diabetes treatment. Many studies have confirmed the alpha-amylase inhibitory activity of plants and their bioactive compounds in vitro, but few studies corroborate these findings in rodents and very few in humans. Thus, despite some encouraging results, more research is required for developing a valuable anti-diabetic therapy using pancreatic alpha-amylase inhibitors of plant origin.
2 型糖尿病的患病率不断上升，以及市售抗糖尿病药物观察到的负面临床结局，促使人们研究新的治疗方法，重点是控制餐后血糖水平。利用天然资源中的碳水化合物消化酶抑制剂可能是一种用比合成药物更少的不良反应来阻断膳食碳水化合物吸收的可行策略。
本文综述了与植物源胰α-淀粉酶抑制剂相关的最新体内外研究证据，并介绍了具有抗淀粉酶活性的酚类天然生物活性化合物。
来自传统植物提取物的胰α-淀粉酶抑制剂是治疗糖尿病的有前途的工具。许多研究已经证实了植物及其生物活性化合物在体外的α-淀粉酶抑制活性，但在啮齿动物中很少有研究证实这些发现，在人类中则更少。因此，尽管有一些令人鼓舞的结果，但仍需要进一步研究，以利用植物源胰α-淀粉酶抑制剂开发有价值的抗糖尿病疗法。
