Evans Stephen J W
Department of Medical Statistics, The London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Br J Clin Pharmacol. 2012 Jun;73(6):973-8. doi: 10.1111/j.1365-2125.2012.04248.x.
Current concerns over the safety of medicines once they have been marketed mean that pharmacoepidemiology is of increasing importance. There are three main areas in which further research is needed. 1 To improve the methods used to make causal inference of effects of medicines and to raise the quality of the reporting and critical appraisal tools, so that the strengths and weaknesses of the new methods can be judged. 2 To apply the methods in areas where randomized trials cannot easily be done, such as in pregnancy. 3 To use electronic health records as fully as possible, using linkage between different databases, ensuring the data are of as high quality as possible. Public health and public perceptions mean that much of pharmacoepidemiology must be done using non-industry funding sources.
当前对药品上市后安全性的担忧意味着药物流行病学变得越来越重要。有三个主要领域需要进一步研究。1. 改进用于对药物效果进行因果推断的方法，提高报告和批判性评估工具的质量，以便能够判断新方法的优缺点。2. 将这些方法应用于难以进行随机试验的领域，如妊娠领域。3. 尽可能充分地利用电子健康记录，通过不同数据库之间的链接，确保数据质量尽可能高。公共卫生和公众认知意味着药物流行病学的大部分工作必须使用非行业资金来源来完成。
