Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
Eur J Neurol. 2012 Aug;19(8):1093-9. doi: 10.1111/j.1468-1331.2012.03681.x. Epub 2012 Feb 23.
This observational community pharmacy-based study aimed to investigate headache characteristics and medication use of persons with regular headache presenting for self-medication.
Participants (n = 1205) completed (i) a questionnaire to assess current headache medication and previous physician diagnosis, (ii) the ID Migraine Screener (ID-M), and (iii) the Migraine Disability Assessment questionnaire.
Forty-four percentage of the study population (n = 528) did not have a physician diagnosis of their headache, and 225 of them (225/528, 42.6%) were found to be ID-M positive. The most commonly used acute headache drugs were paracetamol (used by 62% of the study population), NSAIDs (39%), and combination analgesics (36%). Only 12% of patients physician-diagnosed with migraine used prophylactic migraine medication, and 25% used triptans. About 24% of our sample (n = 292) chronically overused acute medication, which was combination analgesic overuse (n = 166), simple analgesic overuse (n = 130), triptan overuse (n = 19), ergot overuse (n = 6), and opioid overuse (n = 5). Only 14.5% was ever advised to limit intake frequency of acute headache treatments.
This study identified underdiagnosis of migraine, low use of migraine prophylaxis and triptans, and high prevalence of medication overuse amongst subjects seeking self-medication for regular headache. Community pharmacists have a strategic position in education and referral of these self-medicating headache patients.
本项观察性社区药房研究旨在调查因自行用药而就诊的经常头痛患者的头痛特征和用药情况。
参与者(n=1205)完成了(i)一项问卷,以评估当前头痛用药和既往医生诊断,(ii)偏头痛 ID 筛查器(ID-M),和(iii)偏头痛残疾评估问卷。
研究人群中 44%(n=528)的人没有偏头痛的医生诊断,其中 225 人(225/528,42.6%)ID-M 阳性。最常使用的急性头痛药物为对乙酰氨基酚(62%的研究人群使用)、非甾体抗炎药(39%)和复方镇痛药(36%)。仅 12%的偏头痛经医生诊断的患者使用预防性偏头痛药物,25%的患者使用曲坦类药物。约 24%的患者(n=292)慢性滥用急性药物,其中复方镇痛药滥用(n=166)、单纯镇痛药滥用(n=130)、曲坦类药物滥用(n=19)、麦角类药物滥用(n=6)和阿片类药物滥用(n=5)。仅有 14.5%的患者曾被建议限制急性头痛治疗的摄入频率。
本研究发现偏头痛的漏诊率较高,偏头痛预防用药和曲坦类药物的使用率较低,且在因经常头痛而自行用药的患者中,药物滥用的患病率较高。社区药剂师在对这些自行用药的头痛患者进行教育和转介方面具有战略地位。