Mehuys E, Paemeleire K, Van Hees T, Christiaens T, Van Bortel L, Van Tongelen I, Philippe G, Prévôt M L, Evrard B, Piette M, De Bolle L, Remon J-P, Boussery K
Eenheid Farmaceutische Zorg, Universiteit Gent.
J Pharm Belg. 2012 Jun(2):4-10.
This observational community pharmacy-based study aimed to investigate headache characteristics and medication use of persons with regular headache presenting for self-medication.
Participants (n=1205) completed ii) a questionnaire to assess current headache medication and previous physician diagnosis, (ii) the ID Migraine Screener [ID-M] and (iii) the MIDAS questionnaire.
Forty-four % of the study population (n=528) did not have a physician diagnosis of their headache, and 225 of them (225/528, 42.6%) were found to be ID-M positive. The most commonly used acute headache drugs were paracetamol (used by 62% of the study population), NSAIDs (39%) and combination analgesics (36%). Only 12% of patients physician-diagnosed with migraine used prophylactic migraine medication, and 25% used triptans. About 24% of our sample (n=292) chronically overused acute medication, which was combination analgesic overuse (n=166), simple analgesic overuse (n=130), triptan overuse (n=19), ergot overuse (n=6) and opioid overuse (n=51). Only 14.5% was ever advised to limit intake frequency of acute headache treatments.
This study identified underdiagnosis of migraine, low use of migraine prophylaxis and triptans, and high prevalence of medication overuse among subjects seeking self-medication for regular headache. Community pharmacists have a strategic position in education and referral of these self-medicating headache patients.
本基于社区药房的观察性研究旨在调查前来自我药疗的经常头痛患者的头痛特征及用药情况。
参与者(n = 1205)完成了:(i)一份评估当前头痛用药及既往医生诊断的问卷,(ii)ID偏头痛筛查工具[ID - M],以及(iii)偏头痛残疾评定量表问卷。
44%的研究人群(n = 528)没有医生对其头痛的诊断,其中225人(225/528,42.6%)被发现ID - M呈阳性。最常用的急性头痛药物是对乙酰氨基酚(62%的研究人群使用)、非甾体抗炎药(39%)和复方镇痛药(36%)。仅有12%经医生诊断为偏头痛的患者使用预防性偏头痛药物,25%使用曲坦类药物。约24%的样本(n = 292)长期过度使用急性药物,其中复方镇痛药过度使用(n = 166)、单纯镇痛药过度使用(n = 130)、曲坦类药物过度使用(n = 19)、麦角胺过度使用(n = 6)以及阿片类药物过度使用(n = 51)。仅有14.5%的人曾被建议限制急性头痛治疗的摄入频率。
本研究发现偏头痛诊断不足、偏头痛预防性药物和曲坦类药物使用较少,以及在寻求自我药疗的经常头痛患者中药物过度使用的患病率较高。社区药剂师在对这些自我药疗的头痛患者进行教育和转诊方面具有战略地位。