Neurotology Department, Instituto San Lucas Neurociencias, Rosario, Argentina.
Ann N Y Acad Sci. 2011 Sep;1233:E1-7. doi: 10.1111/j.1749-6632.2011.06269.x.
Here, we present findings from a three-step investigation of the effect of galvanic vestibular stimulation (GVS) in normal subjects and in subjects undergoing vestibular rehabilitation (VR). In an initial study, we examined the body sway of 10 normal subjects after one minute of 2 mA GVS. The effect of the stimulation lasted for at least 20 minutes in all subjects and up to two hours in 70% of the subjects. We then compared a group of patients who received conventional VR (40 patients) with a group that received a combination of VR and GVS. Results suggest a significant improvement in the second group. Finally, we attempted to establish the optimal number of GVS sessions and to rule out a placebo effect. Fifteen patients received "systematic" GVS: five sessions, once a week. Five patients received "nonsystematic" galvanic stimulation in a sham protocol, which included two stimulations of the clavicle. These data were analyzed with Fisher's exact test and indicated that the best results were obtained after three sessions of GVS and no placebo effect was observed.
在这里,我们介绍了一项关于前庭刺激(GVS)对正常受试者和接受前庭康复(VR)受试者影响的三步研究结果。在初步研究中,我们在一分钟内对 10 名正常受试者施加 2 mA 的 GVS,观察他们的身体摆动。在所有受试者中,刺激的效果至少持续 20 分钟,在 70%的受试者中持续长达两小时。然后,我们比较了接受常规 VR(40 名患者)的一组患者和接受 VR 和 GVS 联合治疗的一组患者。结果表明第二组有显著改善。最后,我们试图确定最佳的 GVS 治疗次数,并排除安慰剂效应。15 名患者接受了“系统”GVS:五次,每周一次。五名患者按照假协议接受了“非系统”电刺激,包括锁骨两次刺激。这些数据采用 Fisher 确切检验进行分析,结果表明,在进行三次 GVS 后效果最佳,且未观察到安慰剂效应。