Chen Juan, Fu Li, Zhang Li-Yi, Kwong Dora L, Yan Li, Guan Xin-Yuan
Department of Clinical Oncology, The University of Hong Kong, Hong Kong, PR China.
Chin J Cancer. 2012 May;31(5):215-22. doi: 10.5732/cjc.011.10364. Epub 2012 Feb 24.
Nasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China. Deletion of genomic DNA, which occurs during the complex pathogenesis process for NPC, represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs). In many circumstances, loss of TSGs can be detected as diagnostic and prognostic markers in cancer. The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC, with 3p21.1-21.2 and 3p25.2-26.1 being the most frequently deleted minimal regions. In recent years, our research group and others have focused on the identification and characterization of novel target TSGs at 3p, such as RASSF1A, BLU, RBMS3, and CHL1, in the development and progression of NPC. In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment.
鼻咽癌（NPC）是中国南方最常见的恶性肿瘤之一。基因组DNA缺失发生在NPC复杂的发病过程中，是肿瘤抑制基因（TSGs）失活的关键机制。在许多情况下，TSGs的缺失可作为癌症诊断和预后的标志物。3号染色体短臂（3p）是NPC中经常发生缺失的染色体区域，其中3p21.1-21.2和3p25.2-26.1是最常发生缺失的最小区域。近年来，我们研究小组和其他团队专注于鉴定和表征3p上新的靶标TSGs，如RASSF1A、BLU、RBMS3和CHL1，以及它们在NPC发生发展中的作用。在这篇综述中，我们总结了3p上TSGs的最新研究结果，并详细讨论了其中一些基因。更好地了解3p上的TSGs将显著提高我们对NPC发病机制、诊断和治疗的认识。
