BAFF 如何在自身免疫性疾病患者中激活 B 细胞？
How does BAFF activate B cells in patients with autoimmune diseases?
出版信息
Arthritis Res Ther. 2012 Feb 24;14(1):106. doi: 10.1186/ar3729.
Abstract
In a study in a recent issue of , Yoshimoto and colleagues demonstrate that peripheral monocytes from patients with Sjögren's syndrome (SS) produce significantly higher amounts of B cell-activating factor (BAFF) and interleukin-6 (IL-6) in comparison with normal monocytes. This difference exists at baseline and is amplified after stimulation with interferon-gamma. Increased IL-6 secretion is partially suppressed by an anti-BAFF antibody, suggesting that signal transduction pathways mediated by BAFF are implicated in the regulation of IL-6 production by monocytes. The origin and pathways involved in this higher susceptibility to BAFF-driven IL-6 induction by monocytes of patients with SS are still unknown.
摘要
在最近一期的《》杂志上，Yoshimoto 及其同事的研究表明，与正常单核细胞相比，干燥综合征（SS）患者的外周血单核细胞产生的 B 细胞激活因子（BAFF）和白细胞介素 6（IL-6）明显更多。这种差异在基线时就存在，并在干扰素-γ刺激后放大。抗 BAFF 抗体部分抑制了 IL-6 的分泌，表明 BAFF 介导的信号转导途径参与了单核细胞中 IL-6 产生的调节。目前尚不清楚 SS 患者的单核细胞对 BAFF 诱导的 IL-6 诱导具有更高易感性的起源和途径。
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