Arthritis Res Ther. 2012 Feb 24;14(1):106. doi: 10.1186/ar3729.
In a study in a recent issue of , Yoshimoto and colleagues demonstrate that peripheral monocytes from patients with Sjögren's syndrome (SS) produce significantly higher amounts of B cell-activating factor (BAFF) and interleukin-6 (IL-6) in comparison with normal monocytes. This difference exists at baseline and is amplified after stimulation with interferon-gamma. Increased IL-6 secretion is partially suppressed by an anti-BAFF antibody, suggesting that signal transduction pathways mediated by BAFF are implicated in the regulation of IL-6 production by monocytes. The origin and pathways involved in this higher susceptibility to BAFF-driven IL-6 induction by monocytes of patients with SS are still unknown.
在最近一期的《》杂志上,Yoshimoto 及其同事的研究表明,与正常单核细胞相比,干燥综合征(SS)患者的外周血单核细胞产生的 B 细胞激活因子(BAFF)和白细胞介素 6(IL-6)明显更多。这种差异在基线时就存在,并在干扰素-γ刺激后放大。抗 BAFF 抗体部分抑制了 IL-6 的分泌,表明 BAFF 介导的信号转导途径参与了单核细胞中 IL-6 产生的调节。目前尚不清楚 SS 患者的单核细胞对 BAFF 诱导的 IL-6 诱导具有更高易感性的起源和途径。