Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India.
J Cardiovasc Pharmacol. 2012 Jun;59(6):553-62. doi: 10.1097/FJC.0b013e31824f9174.
Hypertension is associated with dyslipidemia, which is a significant risk factor for cardiovascular complications. This study was undertaken to investigate the effects of veratric acid (VA) on blood pressure, plasma, and tissue lipid profile in N-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. Hypertension was induced in adult male albino rats of Wistar strain, weighing 180-220 g, by oral administration of L-NAME (40 mg/kg) in drinking water for 4 weeks. Rats were treated with VA (40 mg/kg) for 4 weeks. L-NAME-treated rats showed significant increase in mean arterial pressure and heart rate. A significant increase in the concentrations of plasma, tissue (liver and kidney) lipids, and lipoproteins and a significant decrease in the concentration of high-density lipoprotein cholesterol were noticed in L-NAME-induced hypertensive rats. The activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase increased significantly in the liver and kidney, whereas the activities of lipoprotein lipase and lecithin cholesterol acyl transferase were decreased significantly in the plasma of hypertensive rats. Histopathology of liver and kidney and in vitro study also confirmed the biochemical findings of this study. Thus, oral administration of VA reduced hyperlipidemia related to the risk of hypertension.
高血压与血脂异常有关，血脂异常是心血管并发症的一个重要危险因素。本研究旨在探讨原儿茶酸（VA）对 N-硝基-L-精氨酸甲酯（L-NAME）诱导的高血压大鼠血压、血浆和组织脂质谱的影响。通过在饮用水中给予 L-NAME（40mg/kg），对成年雄性白化 Wistar 大鼠（体重 180-220g）进行 4 周的口服给药，诱导高血压。用 VA（40mg/kg）治疗 4 周。L-NAME 处理的大鼠平均动脉压和心率显著升高。在 L-NAME 诱导的高血压大鼠中，观察到血浆、组织（肝和肾）脂质和脂蛋白浓度显著升高，高密度脂蛋白胆固醇浓度显著降低。肝和肾中 3-羟基-3-甲基戊二酰辅酶 A（HMG-CoA）还原酶的活性显著增加，而血浆中脂蛋白脂酶和卵磷脂胆固醇酰基转移酶的活性显著降低。肝和肾的组织病理学和体外研究也证实了本研究的生化发现。因此，口服给予 VA 可降低与高血压风险相关的高脂血症。
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