Ntchapda Fidèle, Bonabe Christian, Atsamo Albert Donatien, Kemeta Azambou David Romain, Bekono Fouda Yannick, Imar Djibrine Soudy, Seke Etet Paul F, Théophile Dimo
Department of Biological Sciences, Faculty of Sciences, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.
Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Evid Based Complement Alternat Med. 2020 Sep 18;2020:3678469. doi: 10.1155/2020/3678469. eCollection 2020.
is a plant used against cardiovascular disorders in African folk medicine. We assessed the effects of the aqueous extract of its stem bark on the development of hypertension in L-NAME-induced hypertensive rats.
The animals were administered L-NAME once daily for 3 weeks (25 mg/kg, i.p.), concomitantly with aqueous extract of stem bark (100 and 200 mg/kg, p.o.) or captopril (20 mg/kg, p.o.). Then, hemodynamic and electrocardiographic parameters, oxidative stress markers, and the lipid profile were assessed in the blood and heart, aorta, and kidney homogenates, and histopathological analyses were performed.
L-NAME-induced hypertensive control animals, but not the animals concomitantly treated with extract, displayed increases in the mean arterial blood pressure (21.64% difference, < 0.001, vs. dose 200 mg/kg), systolic arterial blood pressure (21.33%, < 0.001), and the diastolic arterial blood pressure (21.84%, < 0.001). In addition, hypertensive control animals displayed (i) increases in serum triglycerides, total cholesterol, LDL, and creatinine levels, malondialdehyde and transaminase activities, and atherogenic index; (ii) decreases in serum HDL, catalase, reduced glutathione, and nitric oxide; and (iii) aorta wall thickening, inflammatory cell infiltration, and cell loss in the cardiac muscle and renal tissues. As captopril, the extract prevented hypertension-like changes in lipid profile, cardiac, hepatic, and renal affection indicators, and oxidative stress markers.
Our findings suggest that the extract of has antihypertensive and antioxidant effects in L-NAME-induced hypertension rat models. These effects partly justify the traditional medicine use against cardiovascular disorders.
[植物名称]是一种在非洲民间医学中用于治疗心血管疾病的植物。我们评估了其茎皮水提取物对L-NAME诱导的高血压大鼠高血压发展的影响。
动物连续3周每天腹腔注射一次L-NAME（25mg/kg），同时口服茎皮水提取物（100和200mg/kg）或卡托普利（20mg/kg）。然后，评估血液、心脏、主动脉和肾脏匀浆中的血流动力学和心电图参数、氧化应激标志物以及血脂谱，并进行组织病理学分析。
L-NAME诱导的高血压对照动物，而非同时用[植物名称]提取物治疗的动物，平均动脉血压升高（与200mg/kg剂量组相比，差异为21.64%，P<0.001）、收缩压升高（21.33%，P<0.001）和舒张压升高（21.84%，P<0.001）。此外，高血压对照动物表现为：（i）血清甘油三酯、总胆固醇、低密度脂蛋白和肌酐水平、丙二醛和转氨酶活性以及动脉粥样硬化指数升高；（ii）血清高密度脂蛋白、过氧化氢酶、还原型谷胱甘肽和一氧化氮降低；（iii）主动脉壁增厚、炎症细胞浸润以及心肌和肾组织中的细胞丢失。与卡托普利一样，该提取物可预防血脂谱、心脏、肝脏和肾脏损伤指标以及氧化应激标志物的高血压样变化。
我们的研究结果表明，[植物名称]提取物对L-NAME诱导的高血压大鼠模型具有降压和抗氧化作用。这些作用部分证明了传统医学用于治疗心血管疾病的合理性。
