Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstr. 6, 91058 Erlangen, Germany.
J Mater Sci Mater Med. 2012 Oct;23(10):2317-33. doi: 10.1007/s10856-012-4580-z. Epub 2012 Feb 24.
Bioactive glasses (BG) show great promise for bone tissue engineering based on their key properties, e.g., biocompatibility, biodegradability, osteoconductivity as well as osteogenic and angiogenic potential, which make them excellent candidates for bone tissue scaffolds and bone substitute materials. Recent work has shown that dissolution products of bioactive glasses have the potential to induce angiogenesis in addition to their known effect of influencing gene expression and promoting osteoblastic differentiation. One of the most interesting features of BG is their ability to bond both to soft and hard tissues, depending on their composition. To intensify the positive impact of BG for medical applications, there are considerable research efforts on using bioactive glass based platforms as carriers for the encapsulation, delivery and controlled release of bioactive molecules and therapeutic drugs. Different types of bioactive glasses have been considered in combination with different therapeutic drugs, hormones, growth factors and peptides. Using bioactive glasses as drug delivery system combines thus the effectiveness of therapeutic drugs (or bioactive/signaling molecules) with the intrinsic advantages of this inorganic biomaterial. Considering research carried out in the last 15 years, this review presents the different chemical compositions and morphologies of bioactive glasses used as carrier for bioactive molecules and therapeutic drugs and discusses the expanding potential of BG with drug delivery capability focusing in the field of bone tissue engineering.
生物活性玻璃（BG）因其生物相容性、可生物降解性、骨传导性以及成骨和血管生成潜力等关键特性，在骨组织工程中具有广阔的应用前景，使其成为骨组织支架和骨替代材料的理想选择。最近的研究表明，生物活性玻璃的溶解产物除了能够影响基因表达和促进成骨细胞分化外，还有诱导血管生成的潜力。BG 的一个最有趣的特点是，根据其组成，它能够与软组织和硬组织结合。为了增强 BG 在医学应用中的积极影响，研究人员正在努力将基于生物活性玻璃的平台用作封装、输送和控制释放生物活性分子和治疗药物的载体。不同类型的生物活性玻璃已与不同的治疗药物、激素、生长因子和肽结合使用。因此，将生物活性玻璃用作药物输送系统将治疗药物（或生物活性/信号分子）的有效性与这种无机生物材料的固有优势相结合。考虑到过去 15 年的研究，本综述介绍了用作生物活性分子和治疗药物载体的生物活性玻璃的不同化学成分和形态，并讨论了具有药物输送能力的 BG 的扩展潜力，重点关注骨组织工程领域。
