Mehrabi Tina, Mesgar Abdorreza S, Mohammadi Zahra
Biomaterials Laboratory, Division of Biomedical Engineering, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran 1439957131, Iran.
ACS Biomater Sci Eng. 2020 Oct 12;6(10):5399-5430. doi: 10.1021/acsbiomaterials.0c00528. Epub 2020 Sep 10.
The morbidity, mortality, and burden of burn victims and patients with severe diabetic wounds are still high, which leads to an extensively growing demand for novel treatments with high clinical efficacy. Biomaterial-based wound treatment approaches have progressed over time from simple cotton wool dressings to advanced skin substitutes containing cells and growth factors; however, no wound care approach is yet completely satisfying. Bioactive glasses are materials with potential in many areas that exhibit unique features in biomedical applications. Today, bioactive glasses are not only amorphous solid structures that can be used as a substitute in hard tissue but also are promising materials for soft tissue regeneration and wound healing applications. Biologically active elements such as Ag, B, Ca, Ce, Co, Cu, Ga, Mg, Se, Sr, and Zn can be incorporated in glass networks; hence, the superiority of these multifunctional materials over current materials results from their ability to release multiple therapeutic ions in the wound environment, which target different stages of the wound healing process. Bioactive glasses and their dissolution products have high potency for inducing angiogenesis and exerting several biological impacts on cell functions, which are involved in wound healing and some other features that are valuable in wound healing applications, namely hemostatic and antibacterial properties. In this review, we focus on skin structure, the dynamic process of wound healing in injured skin, and existing wound care approaches. The basic concepts of bioactive glasses are reviewed to better understand the relationship between glass structure and its properties. We illustrate the active role of bioactive glasses in wound repair and regeneration. Finally, research studies that have used bioactive glasses in wound healing applications are summarized and the future trends in this field are elaborated.
烧伤患者和重度糖尿病伤口患者的发病率、死亡率和负担仍然很高，这导致对具有高临床疗效的新型治疗方法的需求大幅增长。基于生物材料的伤口治疗方法随着时间的推移已从简单的棉絮敷料发展到含有细胞和生长因子的先进皮肤替代物；然而，目前尚无一种伤口护理方法能完全令人满意。生物活性玻璃是一类在许多领域具有潜力的材料，在生物医学应用中展现出独特特性。如今，生物活性玻璃不仅是可用作硬组织替代物的无定形固体结构，也是软组织再生和伤口愈合应用中有前景的材料。诸如银、硼、钙、铈、钴、铜、镓、镁、硒、锶和锌等生物活性元素可融入玻璃网络；因此，这些多功能材料相较于现有材料的优势在于它们能够在伤口环境中释放多种治疗性离子，这些离子作用于伤口愈合过程的不同阶段。生物活性玻璃及其溶解产物在诱导血管生成以及对细胞功能产生多种生物学影响方面具有高效能，这些细胞功能参与伤口愈合以及伤口愈合应用中其他一些有价值的特性，即止血和抗菌特性。在本综述中，我们聚焦于皮肤结构、受损皮肤伤口愈合的动态过程以及现有的伤口护理方法。对生物活性玻璃的基本概念进行综述，以更好地理解玻璃结构与其性能之间的关系。我们阐述生物活性玻璃在伤口修复和再生中的积极作用。最后，总结了在伤口愈合应用中使用生物活性玻璃的研究，并阐述了该领域的未来趋势。
