Structural biology. How a neurotoxin survives.
作者信息
Adler Michael
机构信息
Neurobehavioral Toxicology Branch, Analytical Toxicology Division, U.S. Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010-5400, USA.
出版信息
Science. 2012 Feb 24;335(6071):928-9. doi: 10.1126/science.1219602.
Abstract
摘要
相似文献
1
Structural biology. How a neurotoxin survives.结构生物学。一种神经毒素的存活方式。
Science. 2012 Feb 24;335(6071):928-9. doi: 10.1126/science.1219602.
2
Molecular composition and extinction coefficient of native botulinum neurotoxin complex produced by Clostridium botulinum hall A strain.由 A 型肉毒梭菌产生的天然肉毒神经毒素复合物的分子组成和消光系数。
Protein J. 2013 Feb;32(2):106-17. doi: 10.1007/s10930-013-9465-6.
3
Enhancement of the endopeptidase activity of botulinum neurotoxin by its associated proteins and dithiothreitol.肉毒杆菌神经毒素的内肽酶活性通过其相关蛋白和二硫苏糖醇得以增强。
Biochemistry. 1999 May 25;38(21):6903-10. doi: 10.1021/bi990086c.
4
Identification and characterization of functional subunits of Clostridium botulinum type A progenitor toxin involved in binding to intestinal microvilli and erythrocytes.肉毒杆菌A 型祖毒素中参与与肠道微绒毛和红细胞结合的功能亚基的鉴定与表征。
FEBS Lett. 2000 Feb 11;467(2-3):179-83. doi: 10.1016/s0014-5793(00)01147-9.
5
Crystallographic evidence for doxorubicin binding to the receptor-binding site in Clostridium botulinum neurotoxin B.阿霉素与肉毒杆菌神经毒素B中受体结合位点结合的晶体学证据。
Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1743-6. doi: 10.1107/s0907444901013531. Epub 2001 Oct 25.
6
Immunological characterization of the subunits of type A botulinum neurotoxin and different components of its associated proteins.A型肉毒杆菌神经毒素亚基及其相关蛋白不同组分的免疫学特性
Toxicon. 2009 May;53(6):616-24. doi: 10.1016/j.toxicon.2009.01.017.
7
Is it possible to accurately determine content of botulinum neurotoxin type A in drug products?能否准确测定药品中A型肉毒杆菌神经毒素的含量？
Drugs R D. 2010;10(2):91-2. doi: 10.2165/11584910-000000000-00000.
8
Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: a new wrinkle in botulinum neurotoxin.A型肉毒杆菌神经毒素轻链金属蛋白酶的超激活：肉毒杆菌神经毒素的一个新问题
J Am Chem Soc. 2006 Apr 5;128(13):4176-7. doi: 10.1021/ja057699z.
9
Comparative role of neurotoxin-associated proteins in the structural stability and endopeptidase activity of botulinum neurotoxin complex types A and E.神经毒素相关蛋白在A型和E型肉毒杆菌神经毒素复合物的结构稳定性和内肽酶活性中的比较作用
Biochemistry. 2007 Dec 11;46(49):14316-24. doi: 10.1021/bi701564f. Epub 2007 Nov 16.
10
Studies on the dissociation of botulinum neurotoxin type A complexes.关于 A 型肉毒神经毒素复合物解离的研究。
Toxicon. 2011 Mar 15;57(4):555-65. doi: 10.1016/j.toxicon.2010.12.019. Epub 2010 Dec 30.
引用本文的文献
1
An Integrative Approach to Computational Modelling of the Gene Regulatory Network Controlling Clostridium botulinum Type A1 Toxin Production.一种用于控制A型1肉毒杆菌毒素产生的基因调控网络计算建模的综合方法。
PLoS Comput Biol. 2016 Nov 17;12(11):e1005205. doi: 10.1371/journal.pcbi.1005205. eCollection 2016 Nov.
2
New Elements To Consider When Modeling the Hazards Associated with Botulinum Neurotoxin in Food.在对食品中肉毒杆菌神经毒素相关危害进行建模时需考虑的新因素。
J Bacteriol. 2015 Sep 8;198(2):204-11. doi: 10.1128/JB.00630-15. Print 2016 Jan 15.
3
Scorpion toxins for the reversal of BoNT-induced paralysis.蝎毒素用于逆转 BoNT 引起的瘫痪。
Bioorg Med Chem Lett. 2013 Dec 15;23(24):6743-6. doi: 10.1016/j.bmcl.2013.10.029. Epub 2013 Oct 25.
本文引用的文献
1
Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.肉毒杆菌神经毒素被 NTNHA 锁闭在一个联锁复合物中。
Science. 2012 Feb 24;335(6071):977-81. doi: 10.1126/science.1214270.
2
Studies on the dissociation of botulinum neurotoxin type A complexes.关于 A 型肉毒神经毒素复合物解离的研究。
Toxicon. 2011 Mar 15;57(4):555-65. doi: 10.1016/j.toxicon.2010.12.019. Epub 2010 Dec 30.
3
Effects of purification on the bioavailability of botulinum neurotoxin type A.纯化对A型肉毒杆菌神经毒素生物利用度的影响。
Toxicology. 2008 Jul 30;249(2-3):123-9. doi: 10.1016/j.tox.2008.04.018. Epub 2008 May 2.
4
Botulism.肉毒中毒
Clin Infect Dis. 2005 Oct 15;41(8):1167-73. doi: 10.1086/444507. Epub 2005 Aug 29.
5
Identification of the major steps in botulinum toxin action.肉毒杆菌毒素作用主要步骤的鉴定。
Annu Rev Pharmacol Toxicol. 2004;44:167-93. doi: 10.1146/annurev.pharmtox.44.101802.121554.
6
Pure botulinum neurotoxin is absorbed from the stomach and small intestine and produces peripheral neuromuscular blockade.纯肉毒杆菌神经毒素可从胃和小肠吸收，并产生外周神经肌肉阻滞作用。
Infect Immun. 1999 Sep;67(9):4708-12. doi: 10.1128/IAI.67.9.4708-4712.1999.
7
Hemagglutinin binding mediated protection of botulinum neurotoxin from proteolysis.血凝素结合介导的肉毒杆菌神经毒素抗蛋白水解作用。
J Nat Toxins. 1998 Oct;7(3):239-53.
8
Antibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms.针对复合形式和非复合形式的A型肉毒杆菌神经毒素结构域的抗体图谱分析。
Infect Immun. 1997 May;65(5):1626-30. doi: 10.1128/iai.65.5.1626-1630.1997.
Zotero 插件