He Yun-Yun, He Kun-Lun, Liu Chun-Lei
General Hospital of Chinese PLA, Beijing 100853, China.
Sheng Li Ke Xue Jin Zhan. 2011 Dec;42(6):419-22.
Endoplasmic reticulum stress is a newly discovered pathway of apoptosis, following the death receptor signaling and mitochondrial pathways. Moderate stress triggers the unfolded protein response (UPR) to rsstore the cell function. However, if the stress is severe and/or prolonged, the ER also initiates apoptotic signaling that includes CHOP, ASK1/JNK and caspases pathways. Recent studies have found that endoplasmic reticulum stress plays an important role in the development of various cardiovascular diseases. Also, extensive research has shown that it can bring about protective effects on myocardial cells through the intervention of the relevant pathways, which may provide us with new therapeutic targets for heart diseases.
内质网应激是继死亡受体信号传导和线粒体途径之后新发现的细胞凋亡途径。适度应激会触发未折叠蛋白反应（UPR）以恢复细胞功能。然而，如果应激严重和/或持续时间长，内质网也会启动包括CHOP、ASK1/JNK和半胱天冬酶途径在内的凋亡信号传导。最近的研究发现，内质网应激在各种心血管疾病的发展中起重要作用。此外，广泛的研究表明，它可以通过干预相关途径对心肌细胞产生保护作用，这可能为我们提供心脏病的新治疗靶点。
