Department of Nephrology Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy.
Semin Nephrol. 2012 Jan;32(1):79-92. doi: 10.1016/j.semnephrol.2011.11.011.
The complex interaction between heart and kidney disease has been increasingly recognized over the recent years. Pathologies within these two organs frequently coexist and, due to organ cross-talk, dysfunction in one often leads to problems in the other. The classification of the various forms of cardio-renal syndrome has made these interactions clearer. To aid in the diagnosis, management and prognosis of these conditions, many novel cardiac and renal biomarkers have emerged to supplement traditional markers which have limited specificity and sensitivity. In this review we will summarize the literature on novel renal behind these and other biomarkers and discuss their potential relevance to the clinical scenarios of cardio-renal syndrome.
近年来，人们越来越认识到心脏和肾脏疾病之间的复杂相互作用。这两个器官中的病理经常共存，由于器官间的相互作用，一个器官的功能障碍常常导致另一个器官出现问题。各种形式的心肾综合征的分类使这些相互作用更加清晰。为了帮助诊断、管理和预测这些疾病，许多新的心脏和肾脏生物标志物已经出现，以补充传统标志物，这些标志物的特异性和敏感性有限。在这篇综述中，我们将总结有关这些和其他生物标志物背后的肾脏新标志物的文献，并讨论它们在心肾综合征临床情况下的潜在相关性。
