Ulmer W
FB Radiologie, Bereich Medizinphysik, St. Marienkrankenhaus Siegen, BRD.
Radiobiol Radiother (Berl). 1990;31(4):313-23.
In conventional radiobiology the survival fraction of cell cultures in the exponential phase is observed by the colony-forming ability, and the linear-quadratic model represents an adequate frame of the numerical adaptation. The measurement of the ATP-concentration of L 1210 cells by 31P-NMR-spectroscopy in dependence of the applied radiation dose can also be used to evaluate dose-response relationships. In particular, the beta-peak of the ATP is suitable to seize the chronological behavior of the cellular ATP-concentration. An access to RBE of a radiation quality is obtained by monitoring the ATP-concentration, and the combination treatment (irradiation and incubation of cisPlatinum) has also been studied with regard to the question of synergistic interactions.
在传统放射生物学中，通过集落形成能力观察处于指数生长期的细胞培养物的存活分数，线性二次模型代表了数值拟合的适当框架。利用31P核磁共振光谱法测量L 1210细胞的ATP浓度与所施加辐射剂量的关系，也可用于评估剂量反应关系。特别是，ATP的β峰适合把握细胞ATP浓度随时间的变化情况。通过监测ATP浓度可获得某种辐射品质的相对生物效应（RBE），并且还研究了联合治疗（照射和顺铂孵育）的协同相互作用问题。
