Suppr超能文献

胃肠道间质瘤管理的最新进展

Updates on the management of gastrointestinal stromal tumors.

作者信息

Bamboat Zubin M, Dematteo Ronald P

机构信息

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

出版信息

Surg Oncol Clin N Am. 2012 Apr;21(2):301-16. doi: 10.1016/j.soc.2011.12.004.

Abstract

Despite being the most common sarcoma of the gastrointestinal tract, gastrointestinal stromal tumor (GIST) has been widely recognized as a unique entity for just over a decade. The advent of tyrosine kinase inhibitors has revolutionized the diagnosis and treatment of GIST. Although surgery remains the only chance for cure, multimodal treatment that includes molecular therapy continues to develop. Optimal management of GIST requires careful radiographic, pathologic, medical, and surgical care, emphasizing the need for a multidisciplinary approach. This review highlights recent developments in the management of GIST.

摘要

尽管胃肠道间质瘤(GIST)是胃肠道最常见的肉瘤,但在仅仅十多年的时间里,它已被广泛公认为一种独特的疾病实体。酪氨酸激酶抑制剂的出现彻底改变了GIST的诊断和治疗方式。虽然手术仍然是治愈的唯一机会,但包括分子治疗在内的多模式治疗仍在不断发展。GIST的最佳管理需要仔细的影像学、病理学、医学和手术护理,强调了多学科方法的必要性。本综述重点介绍了GIST管理方面的最新进展。

相似文献

1
Updates on the management of gastrointestinal stromal tumors.
Surg Oncol Clin N Am. 2012 Apr;21(2):301-16. doi: 10.1016/j.soc.2011.12.004.
2
Gastrointestinal stromal tumor and its targeted therapeutics.
Chin J Cancer. 2011 May;30(5):303-14. doi: 10.5732/cjc.011.10062.
3
Gastrointestinal stromal tumors: who should get imatinib and for how long?
Adv Surg. 2014;48(1):165-83. doi: 10.1016/j.yasu.2014.05.014.
7
Adjuvant therapy of gastrointestinal stromal tumors (GIST).
Curr Treat Options Oncol. 2012 Sep;13(3):277-84. doi: 10.1007/s11864-012-0198-0.
8
Multidisciplinary treatment of gastrointestinal stromal tumors.
Surg Clin North Am. 2009 Feb;89(1):217-33, x. doi: 10.1016/j.suc.2008.10.003.
10
Tyrosine kinase inhibitors in the treatment of unresectable or metastatic gastrointestinal stromal tumors.
Expert Opin Pharmacother. 2014 Oct;15(14):1979-89. doi: 10.1517/14656566.2014.937707. Epub 2014 Jul 3.

引用本文的文献

1
Cytological Diagnosis of Hepatic Metastasis from Rectal Gastrointestinal Stromal Tumor: A Case Report.
Discoveries (Craiova). 2025 Mar 31;13(1):e202. doi: 10.15190/d.2025.1. eCollection 2025 Jan-Mar.
2
Exploring nanotechnology solutions for improved outcomes in gastrointestinal stromal tumors.
Heliyon. 2024 Nov 22;10(23):e40596. doi: 10.1016/j.heliyon.2024.e40596. eCollection 2024 Dec 15.
3
Extremely Rare Synchronous Primary Neoplasms of Meckel's Diverticulum and Colon: a Report of Three Cases.
Indian J Surg Oncol. 2024 Mar;15(1):59-62. doi: 10.1007/s13193-023-01839-0. Epub 2023 Nov 3.
5
A case of jejunal GIST revealed by hematemesis: Unusual situation.
Int J Surg Case Rep. 2022 May;94:107146. doi: 10.1016/j.ijscr.2022.107146. Epub 2022 May 3.
7
Diagnosing gastrointestinal stromal tumors: The utility of fine-needle aspiration cytology versus biopsy.
Cancer Med. 2022 Jul;11(14):2729-2734. doi: 10.1002/cam4.4630. Epub 2022 Mar 17.
8
A rare case of omental extra-gastrointestinal stromal tumor showing two coexisting mutations on exon 14 of the PDGFRA gene.
Gastroenterol Rep (Oxf). 2020 Dec 14;9(4):377-379. doi: 10.1093/gastro/goaa086. eCollection 2021 Aug.
10
Decreasing the burden: An unusual GIST presentation, a case report.
Int J Surg Case Rep. 2020;74:243-246. doi: 10.1016/j.ijscr.2020.08.039. Epub 2020 Aug 29.

本文引用的文献

2
Vatalanib for metastatic gastrointestinal stromal tumour (GIST) resistant to imatinib: final results of a phase II study.
Br J Cancer. 2011 May 24;104(11):1686-90. doi: 10.1038/bjc.2011.151. Epub 2011 May 3.
3
Laparoscopic versus open gastric resections for primary gastrointestinal stromal tumors (GISTs): a size-matched comparison.
Ann Surg Oncol. 2011 Jun;18(6):1599-605. doi: 10.1245/s10434-010-1517-y. Epub 2011 Jan 5.
4
Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations.
Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):314-8. doi: 10.1073/pnas.1009199108. Epub 2010 Dec 20.
5
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours.
Nature. 2010 Oct 14;467(7317):849-53. doi: 10.1038/nature09409. Epub 2010 Oct 3.
6
NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.
J Natl Compr Canc Netw. 2010 Apr;8 Suppl 2(0 2):S1-41; quiz S42-4. doi: 10.6004/jnccn.2010.0116.
8
Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumor treated with sunitinib malate.
Ann Surg Oncol. 2010 Feb;17(2):407-15. doi: 10.1245/s10434-009-0784-y. Epub 2009 Nov 7.
10
Hepatic arterial embolization and chemoembolization for imatinib-resistant gastrointestinal stromal tumors.
Am J Clin Oncol. 2009 Dec;32(6):574-81. doi: 10.1097/COC.0b013e31819cca35.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验