Kingham T Peter, DeMatteo Ronald P
Department of Surgery, Memorial Sloan-Kettering Cancer Center, 303 E. 60th Street, Apt 28E, NY, NY 10022, USA.
Surg Clin North Am. 2009 Feb;89(1):217-33, x. doi: 10.1016/j.suc.2008.10.003.
Gastrointestinal stromal tumor (GIST) has been recognized as a unique tumor only in the last decade. Although rare as a clinical entity, there is much interest in the pathology and treatment because the KIT protooncogene mutation common to most GISTs can be inhibited by imatinib mesylate. Diagnosing and treating GIST requires a multidisciplinary approach, given the combination of pathologic and radiographic evaluation, surgical treatment, and oncologic care required to successfully treat patients with GIST.
胃肠道间质瘤（GIST）直到过去十年才被公认为一种独特的肿瘤。尽管作为一种临床实体较为罕见，但由于大多数GIST共有的KIT原癌基因突变可被甲磺酸伊马替尼抑制，因此对其病理学和治疗方法有很多研究兴趣。鉴于成功治疗GIST患者需要病理和影像学评估、手术治疗以及肿瘤学护理相结合，诊断和治疗GIST需要多学科方法。
