FM Kirby Neurobiology Center, Children's Hospital Boston, and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Neuron. 2012 Feb 23;73(4):638-52. doi: 10.1016/j.neuron.2012.02.008.
After nerve injury maladaptive changes can occur in injured sensory neurons and along the entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain hypersensitivity. The resulting neuropathic pain syndromes present as a complex combination of negative and positive symptoms, which vary enormously from individual to individual. This variation depends on a diversity of underlying pathophysiological changes resulting from the convergence of etiological, genotypic, and environmental factors. The pain phenotype can serve therefore, as a window on underlying pathophysiological neural mechanisms and as a guide for developing personalized pain medicine.
神经损伤后，受伤的感觉神经元和中枢神经系统内的整个伤害感受通路上可能会发生适应性变化，从而导致自发性疼痛或痛觉过敏。由此产生的神经性疼痛综合征表现为一系列复杂的负性和正性症状的组合，个体之间差异极大。这种变化取决于病因、基因型和环境因素汇聚导致的各种潜在病理生理变化。因此，疼痛表型可以作为潜在病理生理神经机制的窗口，并为制定个性化疼痛治疗方案提供指导。
