季节性情感障碍中光诱导的血浆褪黑素抑制
Light-induced plasma melatonin suppression in seasonal affective disorder.
作者信息
Gaddy J R, Stewart K T, Byrne B, Doghramji K, Rollag M D, Brainard G C
机构信息
Department of Psychiatry & Human Behavior, Jefferson Medical College, Philadelphia, PA.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(4):563-8. doi: 10.1016/0278-5846(90)90007-4.
PMID:2236583
Abstract
- Subjects with seasonal affective disorder were exposed to 0, 500 and 1000 lux of white light for one hour beginning at 0300 hours. 2. Plasma samples were taken periodically and analysed for melatonin. 3. Plasma melatonin levels were suppressed by exposure to both 500 and 1000 lux light levels, suggesting that SAD patients show no neuroendocrine insensitivity to light but may show supersensitive responses to light.
摘要
- 患有季节性情感障碍的受试者从凌晨3点开始接受0勒克斯、500勒克斯和1000勒克斯的白光照射1小时。2. 定期采集血浆样本并分析褪黑素。3. 暴露于500勒克斯和1000勒克斯光照水平下均会抑制血浆褪黑素水平，这表明季节性情感障碍患者对光不存在神经内分泌不敏感，但可能对光表现出超敏反应。
Zotero 插件