Molnár Tamás, Vajdovich Péter
National Institute of Environmental Health Risk Assessment, Budapest, Hungary.
Acta Vet Hung. 2012 Mar;60(1):55-68. doi: 10.1556/AVet.2012.005.
In a study of 44 canine patients suffering from histopathologically proven urinary bladder tumour with a high incidence of transitional cell carcinoma (TCC) (n = 35), a close relationship was found either between the disease-free period and the age (r = -0.40) of animals or between the survival times and the age (r = -0.62) of animals after treatment. In addition to the dog breeds known to be prone to have urinary bladder tumour, we found an additional potentially sensitive breed, the Hungarian Vizsla. The median survival times obtained by the applied treatment types were as follow: 'surgery and chemotherapy' (n = 8/44) 475 days, 'surgery alone' (n = 19/44) 240 days, 'chemotherapy alone' (n = 7/44) 31 days, and 'no treatment' (n = 10/44) 7 days (P < 0.001). According to the findings, chemotherapy combined with surgery completed in time is the most effective protocol in the treatment of urinary bladder tumour cases in dogs. A rational and more effective procedure for the assessment and treatment of urinary bladder tumour cases is presented.
在一项针对44只经组织病理学证实患有膀胱肿瘤（移行细胞癌发病率高，n = 35）的犬类患者的研究中，发现动物的无病期与年龄之间（r = -0.40）或治疗后动物的生存时间与年龄之间（r = -0.62）存在密切关系。除了已知易患膀胱肿瘤的犬种外，我们还发现了另一个潜在敏感品种，即匈牙利维兹拉犬。通过应用的治疗类型获得的中位生存时间如下：“手术加化疗”（n = 8/44）475天，“单纯手术”（n = 19/44）240天，“单纯化疗”（n = 7/44）31天，“未治疗”（n = 10/44）7天（P < 0.001）。根据研究结果，及时完成的手术联合化疗是治疗犬膀胱肿瘤病例最有效的方案。本文提出了一种合理且更有效的犬膀胱肿瘤病例评估和治疗程序。
