Rasteiro Ana Mafalda, Sá E Lemos Eva, Oliveira Paula A, Gil da Costa Rui M
CEDIVET, Laboratório Clínico Veterinário, 4200-071 Porto, Portugal.
Garden Veterinary Group, Chippenham SN15 1NQ, UK.
Vet Sci. 2022 Feb 28;9(3):107. doi: 10.3390/vetsci9030107.
Cancer of the urinary bladder is a neoplasm with considerable importance in veterinary medicine, given its high incidence in several domestic animal species and its life-threatening character. Bladder cancer in companion animals shows a complex and still poorly understood biopathology, and this lack of knowledge has limited therapeutic progress over the years. Even so, important advances concerning the identification of tumour markers with clinical applications at the diagnosis, prognosis and therapeutic levels have recently been made, for example, the identification of pathological mutations. Those advances are now facilitating the introduction of targeted therapies. The present review will address such advances, focusing on small animal oncology and providing the reader with an update on this field. When appropriate, comparisons will be drawn with bladder cancer in human patients, as well as with experimental models of the disease.
膀胱癌是一种在兽医学中具有相当重要性的肿瘤，因为它在几种家养动物物种中发病率很高，且具有危及生命的特性。伴侣动物中的膀胱癌表现出复杂且仍未被充分理解的生物病理学，多年来，这种知识的匮乏限制了治疗进展。即便如此，最近在肿瘤标志物的识别方面取得了重要进展，这些标志物在诊断、预后和治疗水平上具有临床应用价值，例如病理突变的识别。这些进展现在正推动靶向治疗的引入。本综述将探讨这些进展，重点关注小动物肿瘤学，并为读者提供该领域的最新信息。在适当的时候，将与人类患者的膀胱癌以及该疾病的实验模型进行比较。
