Guangzhou Fuda Cancer Hospital, Guangzhou, China.
Cryobiology. 2012 Jun;64(3):245-9. doi: 10.1016/j.cryobiol.2012.02.007. Epub 2012 Feb 15.
The purpose of this study was to compare a dual-freeze protocol with a triple-freeze protocol for pulmonary cryoablation in a porcine lung model. Five dual- (10-5-10-5) and five triple-freeze (5-5-5-5-10-5) cryoablations were performed on an exposed operation field in normal porcine lung. Changes in the temperature of the cryoprobes and the diameter of the iceballs were measured during the ablation and pathologic changes in the cryozones (zones of tissue destruction) were reviewed 7 days after the procedure. The diameter of the iceball surface differed between the two protocols. Pathologically, the triple-freeze protocol was associated with a longer complete necrosis zone than the dual-freeze protocol, though the two protocols produced cryolesions and cryozones of similar length, and in both cases there were five areas of tissue destruction. With the same duration of freezing (20 min), the triple-freeze protocol may be better for pulmonary cryoablation than the dual-freeze protocol.
本研究旨在比较双冻法与三冻法在猪肺模型中行肺冷冻消融的效果。在正常猪肺的暴露手术野上进行了 5 次双冻（10-5-10-5）和 5 次三冻（5-5-5-5-10-5）冷冻消融。在消融过程中测量了冷冻探针的温度和冰球的直径，在手术后 7 天观察了冷冻区（组织破坏区）的病理变化。两种方案的冰球表面直径存在差异。在病理上，三冻法比双冻法形成的完全坏死区更长，但两种方案形成的冷冻损伤和冷冻区长度相似，且两种方案都有 5 个组织破坏区。在相同的冷冻时间（20 分钟）下，三冻法可能比双冻法更适合肺冷冻消融。
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