Taylor Polly M, Chengelis Christopher P, Miller Walter R, Parker George A, Gleason Teresa R, Cozzi Elizabeth
Taylor Monroe, Ely, UK.
J Feline Med Surg. 2012 Aug;14(8):516-26. doi: 10.1177/1098612X12440354. Epub 2012 Feb 24.
Propofol emulsion containing benzyl alcohol preservative (BA) was evaluated in cats. Eight (PB) received 1% propofol containing 2% benzyl alcohol and eight (PC) preservative-free propofol. In phase 1, cats were anaesthetised (8 mg/kg) three times at 48 h intervals. In phase 2, cats underwent three anaesthetic procedures at 48 h intervals where anaesthesia was maintained until 24 mg/kg had been administered. Clinical examination and haematological and biochemical analyses were performed regularly. Cardiorespiratory function was monitored throughout anaesthesia. Neurological examination was performed daily for 7 days after phase 2. All cats were euthanased 7 days after phase 2 and examined post mortem to determine any organ toxicity and to comply with regulatory requirements. Anaesthesia was as expected for propofol in cats and no clinically relevant differences between PB and PC were detected. The addition of BA has no additional effect when propofol is used at normal-to-high clinical doses in healthy cats.
对含有苯甲醇防腐剂（BA）的丙泊酚乳剂在猫身上进行了评估。八只猫（PB组）接受了含2%苯甲醇的1%丙泊酚，八只猫（PC组）接受了不含防腐剂的丙泊酚。在第一阶段，猫每隔48小时接受三次麻醉（8毫克/千克）。在第二阶段，猫每隔48小时接受三次麻醉程序，麻醉维持到给药量达到24毫克/千克。定期进行临床检查以及血液学和生化分析。在整个麻醉过程中监测心肺功能。在第二阶段后每天进行7天的神经学检查。所有猫在第二阶段后7天实施安乐死并进行尸检，以确定是否存在任何器官毒性并符合监管要求。丙泊酚对猫的麻醉效果符合预期，未检测到PB组和PC组之间存在临床相关差异。在健康猫中，当丙泊酚以正常至高临床剂量使用时，添加BA没有额外影响。
