Court Michael H
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1039-54. doi: 10.1016/j.cvsm.2013.05.002.
Although it is widely appreciated that cats respond differently to certain drugs compared with other companion animal species, the causes of these differences are poorly understood. This article evaluates published evidence for altered drug effects in cats, focusing on pharmacokinetic differences between cats, dogs, and humans, and the molecular mechanisms underlying these differences. More work is needed to better understand drug metabolism and disposition differences in cats, thereby enabling more rational prescribing of existing medications, and the development of safer drugs for this species.
尽管人们普遍认识到，与其他伴侣动物物种相比，猫对某些药物的反应有所不同，但这些差异的原因却知之甚少。本文评估了已发表的关于猫体内药物效应改变的证据，重点关注猫、狗和人类之间的药代动力学差异，以及这些差异背后的分子机制。需要开展更多研究，以更好地了解猫的药物代谢和处置差异，从而能够更合理地开具现有药物的处方，并为该物种开发更安全的药物。
