Boulton-Jones M
Glasgow Royal Infirmary, Scotland, U.K.
Ren Fail. 1990;12(1):9-13. doi: 10.3109/08860229009066959.
The possibility that inherited glomerular properties predispose individuals to certain glomerulopathies is an exciting new hypothesis. It opens new avenues to the investigation and treatment of patients which may be most easily applied in newly diagnosed diabetics and patients with multiple relapses of minimal change nephropathy. These treatments are unlikely to involve dangerous cytotoxic drugs which have been the fruit of years of investigation concentrated on the immune and inflammatory consequences of glomerular diseases. The differences between the two strains also cast doubt on the wisdom of extrapolating results obtained in the Munich Wistar rat to the rest of the animal kingdom.
遗传的肾小球特性使个体易患某些肾小球疾病，这一可能性是一个令人兴奋的新假说。它为患者的调查和治疗开辟了新途径，这些途径可能最容易应用于新诊断的糖尿病患者和微小病变肾病多次复发的患者。这些治疗不太可能涉及危险的细胞毒性药物，而这些药物是多年来专注于肾小球疾病的免疫和炎症后果研究的成果。这两种品系之间的差异也让人怀疑将在慕尼黑Wistar大鼠身上获得的结果推广到动物界其他物种的做法是否明智。
